What's New?

JFK had Addison's disease

It is difficult to imagine a world without hormones.

Had they not been discovered 100 years ago, John F Kennedy would have lost his life as a young man to a hormonal imbalance, rather than to a bullet as US President.

People with Type 1 diabetes would still die because there would be no insulin therapy to treat them. There would be no oral contraceptive pills and no babies born by IVF.

A century of discovery

It was Ernest Henry Starling who first coined the term 'hormone' in 1905.

He had been dining with academics at Cambridge University and needed a word to describe an agent released into the bloodstream that caused activity in a different part of the body.

It is thought that a colleague who was an authority on Greek poetry suggested the Greek verb for 'excite' or 'arouse', and the deed was done.

Scientists had been aware of such chemicals earlier than this.

In 1855, Thomas Addison described and later gave his name to the syndrome that would have killed JFK.

But he was largely ignored, and when the London Medico-Chirurgical Society would not publish his findings he committed suicide.

A French doctor called Brown-Sequard believed extract of testicles had a rejuvenating effect in man and tested it on himself.

Similarly, George Oliver, a spa physician working in Harrogate in 1893, believed extracts of the adrenal glands might raise low blood pressure and used his son as a guinea-pig.

Since then, more than 30 different hormones have been discovered and have changed the course of medicine and, in particular, the drugs we take.

Professor Ashley Grossman, consultant endocrinologist at Barts and the London Hospital, said: "The most dramatic discovery was insulin.

"Years ago, if you developed Type 1 diabetes then within a few weeks you were dead.

"But the earliest of all of the hormone diseases to be diagnosed was Addison's disease, which was lethal until it was discovered that it was down to the adrenal glands not making cortisone.

"They started giving steroids to these patients and they lived."

But there is a darker side to some of the discoveries.

Flip-side

In the 1950s and 60s, thousands of children born with a condition that means they never reach adult height were given injections of extracts of human pituitary glands from dead bodies.

"We now know that some of those bodies had the human form of mad cow disease, CJD, so a small but significant percentage of those children died," said Professor Grossman.

He said taking steroid medicines over a long period of time, for arthritis for example, could give unwanted side effects.

He said it was possible to develop a condition similar to Cushing's syndrome, which is caused by too much of the hormone cortisol in the body.

This can cause a multitude of problems such as unwanted weight gain, diabetes and osteoporosis.

Since sex hormones like testosterone were found, athletes have abused these steroids to out-perform opponents.

The animals we eat are also fed hormones to make them plumper and meatier.

Future fat fighter

Some fear female sex hormones are entering our water supplies via urine the millions of women using the contraceptive pill.

They say this is changing the sex of male fish and potentially hampering human fertility.

Professor Grossman said most of the hormone research going on now was to look for ways to fight obesity.

Two have already been found - leptin, which tells your brain that it is full, and ghrelin, the hunger hormone that tells you to eat.

"Once we work out how they work we can block them and allow people to control their body shape," he said.

"I'm sure we will continue to see dramatic discoveries. There are still quite a few hormones out there that we have yet to find."

Federica is relieved to be back to her old self

Medical science has come a long way in the 100 years since hormones were named and discovered.

It has helped Federica Costella smile again and see her real face looking back at her when she stands in front of the mirror.

Last summer it was an entirely different story.

Federica was diagnosed with a condition called Cushing's syndrome.

Cushing's occurs when the body makes too much of a hormone called cortisol.

This can cause a number of symptoms, as Federica discovered.

"I started to swell up and put on weight.

"I gained about 15 kilos in three to four months.

"At the beginning I thought it was because I was eating too much and so I dieted. But nothing happened.

"I had a big neck and shoulders. But it wasn't fat.

"It was incredible. My face was like a moon. It swelled like a balloon."

Bruising

Federica became concerned when her skin became very delicate and bruised easily.

"Everything I touched with my legs would break the skin and I would bleed.

"My wounds would take ages to heal. They would last for six to eight months.

"It was very upsetting because I play a lot of sport. It stopped me going to the gym and swimming."

She went to see her GP in Genoa, Italy, where she lived at the time. He suspected it might be diabetes and referred her to a hormone specialist.

Further tests revealed that it was Cushing's syndrome.

There are a number of causes. In Federica's case it was a non-cancerous tumour of a gland in the brain called the pituitary, which controls some of the body's hormones.

The doctors initially decided to give her medication to dampen down her cortisol levels, but it did little to help.

'Complete cure'

In 2001, they decided to operate to remove the tumour.

"They removed it, but nothing changed and I became quite depressed," said Federica.

"I continued with the tablets until 2003 when I told my doctor that I was moving to the UK to study English.

"He told me there was an expert in London, where I would be staying."

In March 2004, after being referred by her London GP, Federica went to Barts and the London Hospital to see Professor Ashley Grossman, a consultant endocrinologist.

He did further tests and decided more of the pituitary gland needed removing in order to cure Federica.

"Now I'm completely cured. It's brilliant. I feel perfect.

"I have to take some hormone supplements because they removed about half of my pituitary, but I feel great.

"I'm now 64 kilos. Before I got Cushing's I was 60 kilos and when I had it I weighed 76 kilos. So I'm back on track.

"I don't feel embarrassed any more and I can do all the things I used to enjoy."

The information you provide will be used to create a register and will be shared with the medical world. It would not be used for other purposes without your expressed permission. Note: This information will not be sold or shared with other companies.