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Singing
neuropathology professor | from
http://record.wustl.edu/news/page/normal/6792.html
The singing
neuropathology professor

Arie Perry puts a new twist on old songs to help students learn about
brain disorders

By Beth Miller

It's not likely many medical students can say they learned music
appreciation in a neuropathology class — except for those in Arie Perry's
class.
Perry, M.D., associate professor of pathology and immunology in the School
of Medicine, takes songs such as "Give Me One Reason," "Desperado" and
"Danny's Song" and adds new lyrics to explain complicated neurological
disorders such as oligodendroglioma, strokes and pituitary adenoma.
 |
|
Photo by Robert Boston |
| Arie
Perry, M.D., sings one of the songs he wrote to second-year medical
students in neuropathology. "He has established himself as one of the
rising stars in neuropathology," says colleague David H. Gutmann. "He
is recognized internationally as an expert in brain tumors." |
Students seem to anticipate the end of the lectures, when Perry pulls
out his guitar and sings one of his songs on a lecture topic. He provides
the lyrics and mp3 files to students so they can follow along.
"It's fun for the students and fun for the professor as well," Perry says.
"I enjoy seeing people perk up, doing something other than hours of
lectures."
The soft-spoken Perry began writing songs about neuropathology as a
resident at the University of Texas-Southwestern Medical School, when an
attending physician at a conference jokingly challenged the residents to
be more entertaining. Perry took it to heart and wrote his first song, "Schwannoma,"
about the peripheral nerve tumor. By the end of his song, Perry had
attracted two or three times more people into the room from those passing
by who wanted to listen.
"Later on, when I began teaching medical students, I found the songs to be
a useful tool for people with better musical memories than rote memories,"
Perry says. "There are a lot of good musicians in medicine."
When writing songs on neuropathology, Perry works to find several pieces
that might fit the rhythm of the topic. "It's a challenge to get the
longer medical terms to fit into a preexisting format," he says.
That rings true in the "Pituitary Adenoma" song, sung to the tune of
"Danny's Song," recorded by Kenny Loggins in the 1970s:
"Patient presents to you with bitemporal hemianopsia
Prolonged amenorrhea, and galactorrhea
MR imaging reveals a sellar neoplasm, pushing up the optic chiasm,
From prolactin forming cytoplasm
Pituitary adenoma, with your disrupted reticulin stroma
You've lost the microacinar pattern of the normal gland
Your cells appear so monomorphic, with nuclei so round and perfect
And salt and pepper nuclear chromatin... "
Perry, who has won several teaching awards — including the distinguished
service teaching award from three classes and the professor of the year
award from the Class of 2007 — says many of the songs he uses were popular
before most of his students were born, which presents more of a challenge
every year as students get younger. "But I hope that they enjoy it enough
to look up the original," he says.
Robert E. Schmidt, M.D., Ph.D., professor of pathology and immunology and
director of the division of neuropathology at the School of Medicine, said
he was surprised at first that Perry's students had taken to the
end-of-lecture songs.
However, he was soon convinced by the warm reception of Perry's songs by
normally intensely focused medical students.
One year, students even held up lighters, a typical rock concert gesture
calling for an encore, during one of Perry's songs, Schmidt said.
Perry's musical background comes from taking folk guitar lessons while
growing up. He also was the lead singer in a rock band in high school, in
which he sang songs by The Who, Journey, Rush, The Beatles and ZZ Top. He
also sang in the school choir and started taking voice lessons at that
time, subsequently spending more of his efforts on classical music.
Perry and his wife, Zenobia, also a musician, sang their vows to each
other at their 1990 wedding, which featured mostly original music.
These days, Perry also sings professionally as associate principal tenor
for the American Kantorei and its Bach at the Sem series at Concordia
Seminary in Clayton. He also sings solos with other St. Louis choirs or at
weddings occasionally.
"I get more nervous at other peoples" weddings than I did at my own,"
Perry says.
Zenobia Perry is the pianist at a local church and has recorded a CD of
original music.
 |
|
Courtesy Photo |
| Arie
Perry, daughter, Jaclyn, 10, wife, Zenobia, and son, Ryan, 13, relax
at their Chesterfield home. |
The musical talent continues in their daughter, Jaclyn, 10, who plays
piano and participates in competitions. The Perrys also have a 13-year-old
son, Ryan, who has autism and a good memory for lyrics, Perry says.
The Perry family is involved with the National Alliance for Autism
Research, based in Princeton, N.J. Perry is on its executive committee for
the Autism Tissue Program, which provides banked brain tissue from
individuals with autism to researchers worldwide. Zenobia even wrote a
theme song for one of the organization's fund-raising walks.
The Jerusalem-born Perry and his family moved to the United States when he
was 6 years old. His father, Gabriel Perry, an obstetrician-gynecologist,
did a residency at Albert Einstein College of Medicine at Yeshiva
University in New York. The family moved to Texas when Perry was 10.
Perry completed his undergraduate work at the University of Texas in 1986
and medical school at the University of Texas-Southwestern in 1990. He
also did his residency at UT-Southwestern.
He did fellowships in surgical pathology and neuropathology and conducted
research at the Mayo Clinic in Rochester, Minn., one of the premier tumor
pathology programs nationwide, before arriving at Washington University in
1998.
Perry's research focuses on tumors of the brain and central nervous
system, which can be difficult to treat. He is involved in translational
research aimed at finding new diagnostic, prognostic and predictive
biomarkers to be used in managing brain tumor patients.
"It's a complicated type of problem, and there are so many different
types," he says.
Some of his work during his fellowship at the Mayo Clinic resulted in new
grading criteria for meningiomas, although commonly perceived to be benign
overall, subsets are aggressive and clinically challenging tumors.
Those criteria have been adopted by the World Health Organization's Tumors
of the Nervous System publication, and are used as a reference for brain
tumor diagnostic pathology around the world.
| Arie Perry
Title: Associate professor of pathology and immunology; medical
director of the Anatomic Pathology Fluorescence in situ hybridization
(FISH) lab
Years at University: Eight
Research interests: Tumors of the brain and central nervous
system; finding new diagnostic and prognostic markers to be used in
managing brain tumor patients
Hobbies: Singing, writing songs, snow skiing, scuba diving |
Perry also is medical director of the Anatomic Pathology Fluorescence
in situ hybridization (FISH) lab, which is used to identify clinically
useful chromosomal abnormalities in a wide variety of tumors, most notably
gliomas (a malignant type of primary brain tumor), breast cancer and
subsets of lymphoma and soft tissue sarcoma.
"As a colleague, Arie is just what you'd want," Schmidt said. "He's an
expert, who has a lot of drive and is a perfectionist. He also has a good
sense of humor, which you have to have in this field."
David H. Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of
Neurology and professor of pediatrics and of genetics at the School of
Medicine, said Perry is wonderful to work with and a valuable colleague.
"He has established himself as one of the rising stars in neuropathology,"
said Gutmann, who also is the co-director of neurooncology at the Siteman
Cancer Center and director of the Neurofibromatosis Center at the School
of Medicine. "He is recognized internationally as an expert in brain
tumors."
Gutmann and Perry have collaborated for many years to refine their ability
to genetically characterize brain tumors. Together, they hope to develop
molecular signatures for brain tumors that might predict their responses
to therapy.
In addition to his teaching and research, Perry provides consults for
difficult surgical cases sent in from medical facilities, mostly
throughout the United States and Canada, but also from other countries.
Schmidt said Perry is one of the best young tumor neropathologists in the
country. "His burgeoning consult service reflects his growing reputation,"
Schmidt said.
Although Perry doesn't work directly with patients, he will often take a
clinical problem back to the lab for research.
"It is still rewarding to know that you are helping the patient in
something that will lead to the right management of the problem," Perry
says.
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June 24-27, 2006, ENDO 2006, Boston Convention & Exhibit Center.
Plenary Lectures Announced for ENDO 2006, Boston, Massachusetts,
June 24-27
ENDO 2006 not only delivers four full days of the latest advances in
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sixteen of the world's foremost leaders of endocrinology. For up-to-date
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www.endo-society.org/endo06
The 2006 plenary topics and speakers are:
* The WHI Hormone Therapy Trial: Timing is Everything
JoAnn Manson MD, DrPH, Brigham & Women's Hospital/Harvard Medical
School
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Michael Mendelsohn, MD, FACP, Tufts University/New England Medical
Center
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Medical Center
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Greet Van den Berghe, MD, PhD, Katholieke Universiteit Leuven,
Belgium
* Prolactin & its Receptor: More than Just the Lactation Mediator
Paul Kelly, PhD, Faculté de Médecine Necker, INSERM, France
(Gerald D. Aurbach Award Lecture)
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Juan Bernal, MD, PhD, Instituto Investigaciones Biomedicas, Madrid,
Spain
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Walter Miller, MD, University of California-San Francisco
(Clinical Investigator Award Lecture)
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Tak Mak, PhD, University of Toronto, Ontario, Canada
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Richard Bergman, PhD, University of Southern California
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Mitchell Lazar, MD, PhD, University of Pennsylvania School of
Medicine
(Edwin B. Astwood Award Lecture)
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Benita Katzenellenbogen, PhD & John Katzenellenbogen, PhD, University
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John Kessler, MD, Northwestern University
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Robert Langer, ScD, Massachusetts Institute of Technology
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David Page, MD, Massachusetts Institute of Technology
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