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please click here.
Amazing what some letters to the editor can do:
One of last week's articles,
which included this phrase
In fact, those little stresses of everyday life will ultimately have a big toll: Stress can damage hearts, cause blood-pressure problems, Cushing's syndrome and more...,
has been retracted! Several members of the message boards wrote to the author of this
piece and/or the author of the book.
Read their comments here.
The paper published this correction Tue,
Apr. 19, 2005
Daily Life: An article about "Hurried Woman Syndrome" that appeared on on
April 12 mistakenly reported that stress can cause Cushing's syndrome.
Read online here.
National Institutes of Health, Vital Medical Resource
The NIH Public Bulletin can be a wonderful resource for you to learn about the
many interesting events and resources targeted for the public sponsored by NIH
Institutes and Centers.
The March 2005 NIH Public Bulletin is online and can be found at:
For prior issues, visit
Patient Issues with Insurance? Employer? Creditor? Patient Advocate
Foundation is a national (US) non-profit organization that serves as an active
liaison between the patient and their insurer, employer and/or creditors to
resolve insurance, job retention and/or debt crisis matters relative to their
diagnosis through case managers, doctors and attorneys. Patient Advocate
Foundation seeks to safeguard patients through effective mediation assuring
access to care, maintenance of employment and preservation of their financial
welcome your articles, letters to the editor, bios and Cushing's
Submit a Story or Article to either the snailmail CUSH Newsletter or to
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These articles are provided in furtherance of the mission of
Cushing's Help and Support to help people with Cushing's or other endocrine
problems, their friends and families through research, education, support,
and advocacy. These news items are intended to serve as background
concerning its subject for patient-physician discussions and discussions
Cushing's Help and Support Message Board Members.
These articles contain
information by authors and publishers that is subject to the Copyright Act
of 1976, and "fair use doctrine" therein, effective on January 1, 1978 (17
U.S.C. § 101 et seq.). Cushing's Help and Support makes no representation
that the information and any of the views or comments contained in these
articles are completely accurate or current. Cushing's Help and Support
takes no responsibility for any of the content.
Epstein-Barr virus associated with
smooth-muscle tumours in HIV patients
Michael Carter, Wednesday, April 27, 2005
HIV-positive individuals who develop smooth-muscle tumours typically develop
these cancers in multiple and unusual sites, according to a Thai study
published in the May 15th edition of Clinical Infectious Diseases. The
investigators also established an association between infection with
Epstein-Barr virus and the development of smooth-muscle tumours in
Kaposi’s sarcoma, lymphoma and cervical cancer occur with increased
frequency in HIV-positive patients and are used to diagnose an individual’s
progression to AIDS. However, there have been case reports indicating an
increased incidence of smooth-muscle tumours in HIV-positive children, and
in rare instances, adults. Earlier studies suggest that smooth-muscle
tumours in individuals with immune suppression, such as HIV-negative
transplant patients are associated with infection with Epstein-Barr virus.
Investigators from Chulalongkorn University in Bangkok wished to describe
clinical manifestation of smooth-muscle tumours in HIV-positive patients and
to demonstrate an association between smooth muscle tissues and Epstein-Barr
virus using a variety of testing methods, including immunohistochemical
analysis, in situ hybridization and Epstein-Barr virus PCR testing.
Samples of tumours were obtained for immunohistochemical analaysis and in
situ hybridization. HIV and Epstein-Barr virus viral load were also measured
and data on individuals’ CD4 cell count were obtained.
A total of nine HIV-positive patients with smooth muscle tumours were
identified during the study period (late 2001 – late 2003). Eight were
adults (age range 26 – 39-years) infected with HIV through heterosexual sex,
the other patient being a vertically infected four-year-old child. By the
end of the study period, six patients were alive and three had died. All the
patients had a CD4 cell count below 200 cells/mm3 (range 3 – 150 cells/mm3)
when their smooth muscle tumours were diagnosed, two were coinfected with
hepatitis B virus, and five individuals had already been diagnosed with at
least one AIDS-defining illness.
All but two patients developed smooth-muscle tumours in multiple sites. In
HIV-negative individuals smooth-muscle tissue tumours tend only to develop
in one site, usually affecting the genitourinary or gastrointestinal tract.
None of the smooth muscle tissue tumours seen in this study affected these
sites. Nine cases of smooth muscle tissue affecting the epidura were
diagnosed. In addition cases affecting the vocal cords (two instances),
adrenal glands (two instances) abdominal wall (two instances), iris (one
case), liver (one case), lung (once case), orbit (one case) and thigh (one
case) were also diagnosed.
In situ hybridisation using samples obtained from tumour sites provided
results positive for Epstein-Barr virus for all nine patients. Seriological
anaylsis indicated past Epstein-Barr virus infection in seven patients and
Epstein-Barr virus PCR testing was positive for two patients.
“Our series, which is, to our knowledge the largest case series published,
provides additional evidence of the association between smooth-muscle
tumours with Epstein-Barr virus in patients with AIDS”, write the
Removal of tumours followed by HAART was associated with a good prognosis
for six patients. However, three individuals died. All three of these
patients had smooth-muscle tumours in multiple sites, had been diagnosed
with an AIDS-defining illness and had low CD4 cell counts (range 5 – 150
“Smooth-muscle tumours in patients with AIDS typically arise in multiple and
very unusual sites” conclude the investigators, adding “our series also
suggests an association between Epstein-Barr virus infection and the
development of smooth-muscle tumours.”
Suankratay C et al. Epstein-Barr virus infection-associated smooth-muscle
tumours in patients with AIDS. Clin Infect Dis 40 (on-line edition), 2005.
Adrenal / CAH
Prenatal genetic screening promoted
Express News Service
Pune, India, April 23: The incidence of genetic disorders like hypothyroidism
and congenital adrenal hyperplasia in India is among the highest in the world.
Towards raising awareness about these diseases among doctors and the general
population, State health minister Vimal Mundada will inaugurate the Indian
Society for Genetic Screening (ISGS) at a function to be held at the Le Meridien
tomorrow. Dr Mrudula Phadke, vice-chancellor of Maharashtra Health University,
has been elected as president of ISGS and Dr Prakash Gambhir as vice-president.
‘‘Pre- and neonatal screening can help minimise and even cure mental retardation
arising out of genetic defects,’’ says Dr S Suresh from Chennai, who has done
pioneering work in the field. He says there’s almost no genetic screening in
India presently. ‘‘It’s just a matter of some simple tests which will save
someone from lifelong agony,’’ he adds.
Tests are available for Down’s syndrome, hypothyroidism, congenital adrenal
hyperplasia, galactosmia, and G-6-PD deficiency. These defects can be treated
with medication and dietary support if detected early, and can prevent mental
retardation in a baby. At present genetic screening is available in some clinics
in Mumbai and at one hospital in Pune.
The society will also lobby with the government to make genetic screening
compulsory. The society is hosting a conference concurrent with the
Genetic defects in India
1 in 700 births: Down’s syndrome
1 in 1,850 births: Hypothyroidism
1 in 2,000 births: Congenital Adrenal Hyperplasia
1 in 3,000 births: G-6-PD deficiency
3 pc of population: Thalassaemia
April 24, 2005
Study: Happier could mean healthier
Positive people have better immunity, less stress, stronger cardio system,
By Jamie Talan
If you're looking for a good reason to be happy, consider this: Happier
people may be healthier.
Scientists have known for years that depressed people are at higher risk for
all sorts of medical illnesses. Dr. Andrew Steptoe, a professor of
psychology at University College London and lead author of the study, wanted
to test whether people who are more positive about their world had less risk
Steptoe and colleagues asked 200 middle-aged men and women to keep daily
journals, conducted "brain teaser" type tests to induce a bit of mental
stress in the laboratory and then took blood samples to see whether they
could identify biological markers that correlated with their daily moods.
They found that the happiest of the lot had reduced stress hormones, a
stronger immune system and a more robust cardiovascular system.
"Happy people may have better prospects for good health," said Steptoe,
whose study was published in the Proceedings of the National Academy of
People in the study were asked to fill out mood diaries 30 times a day over
two days, one during the workweek and the other on the weekend. In their
blood, scientists looked for levels of cortisol, a stress hormone, and a
blood substance called fibrinogen, a marker of heart health.
People who rated themselves happier had 20 percent to 30 percent lower
levels of cortisol compared with those who didn't find much good to record
during the study. This level stayed consistent both days.
Fibrinogen is a part of the stress response, and scientists found that the
levels were significantly smaller in happier people.
"We wanted to see what happens in a normal, everyday life," said Steptoe.
"The differences are not very large, but if this pattern persists for days,
months or years, it could have a heavy toll on the body."
• If you've been diagnosed with Cushing's, please
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and will be shared with the medical world. It would not be used
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person responsible for the creation of this register. If you
have any questions you may contact her at
You do not have to be a member of CUSH to fill out this
questionnaire, as long as you are a Cushing’s patient. We do not
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|Upcoming Conventions, Meetings and Seminars:|
May 3, 2005, Greater Chicago Pituitary Support Group: Prolactinomas. More info here »
14, 2005, New England Meeting, Albany, NY.
More info here »
May 15, 2005, 11 a.m. to 3:00 p.m., NIH Share the Health: Health and Fitness Expo,
Wheaton, MD. More info here »
19, 2005, Third Thursdays. A new DC Metro Area once
monthly meeting for lunch.
More info here »
June 4-7, 2005, ENDO 2005, San Diego. Mainly for physicians, but patients may attend. More info here »
July 21-24, 2005, MAGIC Foundation Convention, Chicago, OHare Marriott. For Growth Hormone patients and their families. More info here »
July 23-31, 2005, Pituitary Awareness Week, Australian Pituitary Foundation, Ph: 02 9594 5550 Email: firstname.lastname@example.org
July 23, 2005, (Australia) NSW APF Patient Education Seminar,
Royal Prince Alfred Hospital, Camperdown, Ph: 02 9594 5550 Email: email@example.com
August 6-7, 2005, The Diabetes Insipidus Foundation,
Second Annual Conference, The Diabetes Insipidus Foundation, Sheraton Inner Harbor, Baltimore, Maryland USA, Contact: 5203 New Prospect Drive, Ellicott City, MD 21043 USA, Email: firstname.lastname@example.org, More info here »
September 3, 2005, (Scotland) 6th National Conference,
The Pituitary Foundation, University of Edinburgh, Scotland, UK, More info here »
September 7, 2005, (Australia) Annual Scientific Meeting, Endocrine Society of Australia,
For health professionals, Perth Convention Centre, WA, More info here »
October 8, 2005, (Australia) APF [Australian Pituitary Foundation] Annual General Meeting, Ph: 02 9594 5550, Email: email@example.com
More upcoming local meetings are listed here »
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