Cushing's Help RSS Feed

Comment added to Catherine J (Catherine Jones), Pituitary Bio

Tue, 21 May 2013 09:15:44 -0400

Wow! Yours is one of the “phew” mine wasn’t nearly so rough stories out there...

Hypercortisolism Is Associated With Increased Coronary Arterial Atherosclerosis

Tue, 21 May 2013 09:09:13 -0400

The study aims to determine whether Cushing's syndrome (CS) patients have increased coronary atherosclerosis. Increased coronary calcifications and noncalcified coronary plaque volumes are present in patients with active or previous hypercortisolism. Increased atherosclerosis may contribute to the increased rates of cardiovascular morbidity and mortality in patients with glucocorticoid excess.

3 Comments added to Jenny (Jenny), Adrenal Bio

Tue, 21 May 2013 08:51:31 -0400

Jenny….I had a very similar story to yours, minus the broken hip issues. I was 37 and thought my weight gain was all related to moves and changes etc. Dont be scared by all the stories you read….

Jenny (Jenny), Adrenal Bio

Sun, 19 May 2013 16:54:34 -0400

Jenny is from San Clemente, California. She is having adrenal surgery on June 11, 2013.

Classifying hypertension

Sun, 19 May 2013 16:33:28 -0400

The vast majority of patients have essential or primary hypertension, while only about 5-10% of patients have secondary hypertension, which are mainly caused by kidney and hormonal conditions like renal artery stenosis, hyperthyroidism, Cushing’s syndrome, and even pregnancy, among others.

Pulling Myself up by my Frayed and Worn Out Bootstraps

Fri, 17 May 2013 19:47:29 -0400

A blog post by Autumn...We will be wounded. Scars will remain. But, it is the way that we cope with the onslaught of trauma that defines us – NOT THE DISEASE. I am not Cushing’s. I am Autumn. I will pull myself up by these tattered, frayed and worn out bootstraps - and I will survive.

Texas Medical Center Announces Brain, Spine And Pituitary Tumor Center

Fri, 17 May 2013 16:17:36 -0400

The Texas Medical Center announced that a brain and pituitary tumor treatment center will be established at the Methodist Hospital.

Comment added to SoVeryTired, Undiagnosed Bio

Thu, 16 May 2013 21:33:11 -0400

...Years ago I had steroids injected in my neck due to a severe burn due to a scarf around my neck getting pulled down into a snowmobile engine–long story. Would this cause Cushing’s? I don’t have the back hump but my Grandmother and Mom did. Any thoughts?

Friday is the last day! Help Grow the Rare Disease Congressional Caucus

Thu, 16 May 2013 21:25:05 -0400

Help us strengthen the rare disease community's voice on Capitol Hill! Please take 3 minutes to ask your Member of Congress to join the Rare Disease Caucus.

Catherine J (Catherine Jones), Pituitary Bio

Thu, 16 May 2013 21:24:51 -0400

Catherine J is from Prosser, Washington. She had 3 pituitary surgeries, gamma knife radiation, and a BLA>

Hyperthyroidism due to thyroid stimulating hormone secretion after surgery for Cushing's syndrome: A novel cause of the syndrome of inappropriate secretion of thyroid stimulating hormone

Tue, 14 May 2013 14:18:18 -0400

Hyperthyroidism with the syndrome of inappropriate secretion of thyroid stimulating hormone (TSH) (SITSH) occurred by a decrease in hydrocortisone dose after surgery for Cushing's syndrome. This is a novel cause of SITSH.

Donors and Subscribers, 2013

Sun, 12 May 2013 22:20:47 -0400

Many thanks to these 2013 Donors and Subscribers! We couldn't do it without you!

New donor added 5/12/13.

Daily News Summary

cushingshelp@gmail.com — Sun, 12 May 2013 22:20:58 -0400

Something new of interest to Cushies most every day.

Comment added to MR Brain Spectroscopy Detects Damage In The Hippocampus Of Patients Exposed To Excess Cortisol

Sat, 11 May 2013 05:51:22 -0400

Thank you very much for sharing this. I too have terrible memory post Cushings Disease. Always suspected it was something to do with Cushings and here it is…some research to back it all up.

MR Brain Spectroscopy Detects Damage In The Hippocampus Of Patients Exposed To Excess Cortisol

Wed, 08 May 2013 17:12:45 -0400

New research shows that patients who are "biochemically cured" of Cushing's syndrome have levels of brain metabolites which are associated with neural damage. This will have implications for treatment of Cushing's patients, but might also suggest that patients using high levels of glucocorticoid drugs may suffer similar long-term problems.

Male Only bios. New bio added 5/7/13

cushingshelp@gmail.com — Tue, 07 May 2013 16:59:52 -0400

Male Only bios updated. This list currently includes only bios from 2007-2010. Older pre-2007 adrenal and ectopic bios have been added. Names A through D of the older pituitary bios have been added now.

Salk scientists find potential therapeutic target for Cushing's disease

Tue, 07 May 2013 16:52:06 -0400

Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

The CushieWiki is back. Last updated 5/9/2013.

cushingshelp@gmail.com — Sun, 12 May 2013 22:21:23 -0400

The CushieWiki could use YOUR input. Please help us with this body of Cushing's knowledge:

Contributors can add and edit information to be sure that we have the most current knowledge available.
Thanks!

Abnormal Metabolites Found in Cured Cushing’s Patients

Fri, 03 May 2013 14:53:41 -0400

Patients with Cushing's syndrome have abnormal brain metabolites suggestive of neuronal dysfunction even after they appeared to have been cured, according to a study presented at the annual European Congress of Endocrinology, held from April 27 to May 1 in Copenhagen.

Green Creek woman battles Cushing's disease

Fri, 03 May 2013 14:41:57 -0400

Within two days they were in his office. Dr. Nelson Oyesiku examined Heather Cash and diagnosed her with Cushing's disease.

The doctor also recommended that the pituitary tumor be removed immediately.

Case study shows chronic marijuana use associated with hypopituitarism

Fri, 03 May 2013 11:12:00 -0400

According to study authors Richard Pinsker, MD, FACE, and Hineshkumar Upadhyay, MD, of Jamaica Hospital Medical Center and colleagues, a 37-year-old male demonstrated low testosterone and pituitary hormone levels associated with 15 years of daily marijuana use.

Diagnostic performance of salivary cortisol in the diagnosis of Cushing's syndrome, adrenal incidentaloma and adrenal insufficiency

Wed, 01 May 2013 12:11:35 -0400

Salivary cortisol has been recently suggested for studies on the hypothalamic-pituitary-adrenal (HPA) axis: lack of circadian rhythm is a marker of Cushing's syndrome (CS), and some authors report that low salivary cortisol levels may be a marker of adrenal insufficiency. The aim of our study was to define the role of salivary cortisol in specific diagnostic setting of HPA axis disease.

Know Your Number

Mon, 29 Apr 2013 19:12:50 -0400

In honor of Cushing's Awareness day, Novartis Pharmaceuticals Corporation is kicking off “Know Your Number,” an important new program emphasizing the importance of cortisol regulation.

Ectopic Cushing's Syndrome Secondary to Pulmonary Carcinoid Tumor

Fri, 26 Apr 2013 13:21:28 -0400

Adrenocorticotropic hormone (ACTH) overproduction within the pituitary gland or ectopically leads to hypercortisolism. In this study a case of Cushing's syndrome caused by an ectopic ACTH-secreting carcinoid tumor in lung is discussed...

Updated Upcoming Meetings

cushingshelp@gmail.com — Wed, 24 Apr 2013 20:38:03 -0400

Updated Upcoming Meetings (Updated 4/24/13)

Adult growth hormone deficiency – benefits, side effects, and risks of growth hormone replacement

Wed, 24 Apr 2013 10:16:35 -0400

Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity and increased mortality.

Cushing's on TV

Tue, 23 Apr 2013 10:24:33 -0400

Sara Cook, a patient with Cushing’s disease shares her personal story and her success with a medicine that blocks the activity of excess cortisol and Dr. James Findling shares his personal medical expertise. The Balancing Act segment will air on Lifetime TV.

Cushing's Overview from the New York Times

Sat, 20 Apr 2013 16:55:44 -0400

Cushing’s disease is a condition in which the pituitary gland releases too much adrenocorticotropic hormone (ACTH). The pituitary gland is an organ of the endocrine system.

Cushing's disease is a form of Cushing syndrome...

New comment on I Was Diagnosed with a Pituitary Tumor…Now What?.

Sat, 20 Apr 2013 16:21:09 -0400

Thanks for sharing your story! The exact cause of pituitary tumor is not known. Treatment usually includes surgery to remove the tumor, though in some cases drug therapy may be used to reduce tumor size. Replacement hormone therapy is often prescribed following surgery and/or radiation.

Cushing’s syndrome increased risk for coronary arterial atherosclerosis

Sat, 20 Apr 2013 11:22:28 -0400

In a recent study supported by the NIH, researchers determined that patients with Cushing’s syndrome have a greater risk for developing coronary arterial atherosclerosis, increasing their rate of cardiovascular morbidity.

Supporting Rare Pituitary Disease Awareness in Congress: H. CON. RES. 31

Sat, 20 Apr 2013 11:25:22 -0400

Write to your senators and congresspeople - H. CON. RES. 31 Supporting Rare Pituitary Disease Awareness

Cushing's on Capitol Hill

Thu, 18 Apr 2013 12:01:40 -0400

The Rare Disease Congressional Caucus is a forum for members of Congress to voice constituent concerns, share ideas, and build support for legislation that will improve the lives of people with rare diseases. The goal of the meeting in April is to educate the members of the Caucus about rare pituitary disorders, including Cushing’s Disease - area that has received little to no recognition among legislators. The meeting will serve as an opportunity to raise legislators’ awareness about multiple issues that patients with rare pituitary diseases, such as Cushing’s disease and Acromegaly, face in their everyday lives.

Cushing's Awareness Day!

Mon, 08 Apr 2013 17:10:06 -0400

Cushing's Awareness Day is April 8 each year in commemoration of Dr. Harvey Cushing's birthday.

Latest Posts in the 2013 Cushing's Awareness Challenge

Thu, 04 Apr 2013 10:35:19 -0400

We have a new blogger today - Gail blogs at My Life as A Cushie

Please read these posts and comment on them, if just to give a bit of encouragement.

Life With Cushing's
10 Things I Couldn't Live Without -Aside from family, friends, water, food, shelter, etc., here are the 10 things I would have a very hard time living without. 1. My Laptop I use my...

Cushing's Awareness Challenge 2013 Starts TODAY!

Mon, 01 Apr 2013 11:35:02 -0400

Do you blog? Want to get started?
Since April 8 is Cushing's Awareness Day, several people got their heads together to create this blogging challenge.
All you have to do is blog about something Cushing's related for the 30 days of April.

Multisystem Morbidity and Mortality in Cushings Syndrome: a Cohort Study

Thu, 28 Mar 2013 09:57:19 -0400

To examine the risks for mortality, cardiovascular disease, fractures, peptic ulcers, and infections in CS patients before and after treatment.Cushing’s syndrome (CS) is associated with hypercoagulability, insulin resistance, hypertension, bone loss, and immunosuppression. To date, no adequately large cohort study has been performed to assess the multisystem effects of CS. It was concluded that despite the apparently benign character of the disease, CS is associated with clearly increased mortality and multisystem morbidity, even before diagnosis and treatment

Can You Help?

Thu, 28 Mar 2013 07:08:18 -0400

Carl writes:

My mom was diagnosed with Cushings in Nov. 2012 and had her pituitary tumor removed in Jan 2013. She is now on a cortisol replacement steroid. She is having severe bone, muscle, and joint pain. Does anyone know how long these symptoms will last and if there is any medication that she can take to help the pain.

Early diagnosis of pediatric Cushing’s disease improved surgical outcomes

Wed, 27 Mar 2013 21:58:48 -0400

Early postoperative endocrine testing could predict lasting remission among pediatric patients with Cushing’s disease, according to recent study findings published in the Journal of Clinical Endocrinology & Metabolism. Other findings suggest early diagnosis has the potential to improve surgical outcomes due to an association with younger age, smaller adenomas and lack of dural invasion.

Depressed Mood and Other Psychiatric Manifestations of Cushing's Syndrome: Relationship to Hormone Levels

Mon, 18 Mar 2013 21:03:43 -0400

Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level. The relationship of depressed mood and hormone levels was examined. Low ACTH levels were significantly associated with milder rather than pronounced depressed mood. The implications of the similarities in psychiatric manifestations between Cushing's syndrome and the primary affective disorders are discussed.

Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome

Thu, 14 Mar 2013 18:35:57 -0400

Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome.

Cushing's Help is on Pinterest

Thu, 14 Mar 2013 08:07:16 -0400

Cushing's syndrome is a rare endocrine disorder caused by too much cortisol. The source can be pituitary (Cushing's disease), adrenal, ectopic, or steroid use.

Check out our images and videos!

Signifor® (Pasireotide) is now Commercially Available

Thu, 14 Mar 2013 06:38:22 -0400

November 7, 2012 The US Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) voted unanimously in support of the use of Signifor® (pasireotide) for the treatment of patients with Cushing's disease who require medical therapeutic intervention. The recommendation was based on data from clinical trials of pasireotide, including PASPORT-CUSHINGS (PASireotide clinical trial PORTfolio - CUSHING'S disease), the largest randomized Phase III study to evaluate a medical therapy in patients with Cushing's disease.

Cushing's Syndrome, Prostate Cancer and Adrenocortical Carcinoma

Mon, 11 Mar 2013 15:48:25 -0400

Orphagen has identified and characterized small molecule antagonists to steroidogenic factor-1 (SF-1). SF-1 binds to and regulates DNA promoter elements in the major transporters and enzymes required for adrenal steroid synthesis. It is also required for development of the adrenal gland. SF-1 antagonists inhibit cortisol secretion in adrenal cells and have potential application in two orphan indications, Cushing’s syndrome and adrenocortical carcinoma. In addition, SF-1 appears to have an important role in the progression of advanced prostate cancer.

Predictors of Mortality, CVD Risk in Cushing's Disease ID'd

Thu, 28 Feb 2013 13:54:36 -0500

A number of factors, including the duration of glucocorticoid exposure, older age at diagnosis, and preoperative adrenocorticotropic hormone (ACTH) concentration, are associated with a higher risk of mortality in patients treated for Cushing's disease (CD), according to research published online in the Journal of Clinical Endocrinology & Metabolism.

Early Detection, Treatment Needed To Reduce Risk Of Death, Cardiovascular Disease In Cushing's Disease Patients

Wed, 20 Feb 2013 17:30:14 -0500

Even after successful treatment, patients with Cushing's disease who were older when diagnosed or had prolonged exposure to excess cortisol face a greater risk of dying or developing cardiovascular disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Add YOUR Location

Sat, 09 Feb 2013 11:27:50 -0500

Add your location and diagnosis to our Cushing's World Map

New Helpful Doctor added to British Columbia, Canada

Sun, 06 Jan 2013 21:32:41 -0500

Endocrinologist, Dr. David Shu

Dr Oz will be covering Cushing's on Thursday, December 20

Wed, 19 Dec 2012 09:57:45 -0500

Lori Burkhoff, a 34-year-old mother from Long Island, NY, who came to Ohio State seeking a cure for Cushing’s disease, will be featured on The Dr. Oz Show along with Neurosurgeon Daniel Prevedello, MD, and Otolaryngology (ENT) Surgeon Ricardo Carrau, MD.

US FDA approves Novartis' Signifor for first medication to treat Cushing's disease

Mon, 17 Dec 2012 10:02:06 -0500

The US Food and Drug Administration (FDA) has approved Novartis' Signifor (pasireotide) injection for the treatment of adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.

RARE Video Project – Submission Form

Thu, 06 Dec 2012 05:57:08 -0500

We are working with an award-winning filmmaking team to select submissions that will be compiled together to create a visual storyline of the years of your ongoing journey. This is your chance to share the moments that you see and experience with a global audience.

Cushing Syndrome Overview

Thu, 06 Dec 2012 05:35:13 -0500

Cushing’s syndrome (pronounced KOOSH-ingz SIN-drohm) is a condition that occurs when a person’s body tissues are exposed over time to too much of the hormone cortisol (pronounced KAWR-tuh-sawl). The syndrome can be caused by taking certain medicines or, less commonly, it can be caused by noncancerous or cancerous tumors. Cushing’s syndrome includes a range of symptoms, but they can be treated and, in most cases, the syndrome can be cured.

Mifepristone: is there a place in the treatment of Cushing's disease?

Tue, 04 Dec 2012 22:38:44 -0500

The purpose was to review the use of mifepristone in the treatment of Cushing's syndrome (CS) in the context of other recently published studies. We review the use of mifepristone, as published in the recent Study of the Efficacy and Safety of Mifepristone in the Treatment of Endogenous Cushing's Syndrome (SEISMIC). We also review the multiple case reports and case series of mifepristone use in CS.

8th Annual Convention for Adults with Pituitary Disorders

Thu, 29 Nov 2012 22:09:00 -0500

The confirmed convention dates for the 8th Annual Convention for Adults with Pituitary Disorders are Friday, April 19th, 2013-Sunday, April 21st, 2013 in Las Vegas, NV. The Tuscany Suites and Casino Hotel has been chosen as the hotel for this convention.

Cushing's Syndrome after Hemodialysis for 21 Years

Sun, 25 Nov 2012 09:36:12 -0500

This is the first documented case of adrenal Cushing's syndrome in a patient on long-term hemodialysis, although several authors have reported a relation between hypokalemia and primary hyperaldosteronism in hemodialysis patients.

Novartis drug Signifor® recommended by FDA advisory committee for approval to treat patients with Cushing's disease

Thu, 08 Nov 2012 14:14:04 -0500

For the treatment of Cushing's disease, pasireotide has been studied as a twice-daily subcutaneous (sc) injection and is currently being evaluated as a long-acting release (LAR), once-monthly intramuscular (IM) injection as part of a global Phase III program in Cushing's disease and acromegaly

Get everything from this feed...

cushingshelp@gmail.com — Sat, 24 Nov 2012 09:59:02 -0500

This feed usually has at least 50 items. Click the link to see them all.

Evaluation of depression, quality of life and body image in patients with Cushing's disease

Wed, 07 Nov 2012 10:39:32 -0500

The aim of this study was to evaluate patients with Cushing’s disease (CD) who had undergone transsphenoidal surgery in terms of depression, quality of life (QoL), and perception of body image in comparison to healthy controls.

Robotic versus laparoscopic adrenalectomy in obese patients

Sun, 04 Nov 2012 19:26:17 -0500

The aim of this study is to compare perioperative outcomes of RA versus LA in obese patients. The study did not show any difference in perioperative outcomes between RA and LA in obese patients. These results suggest that the difficulties in maintaining exposure and dissection in obese patients nullify the advantages of robotic articulating versus rigid laparoscopic instruments in adrenal surgery.

A Quarter of a Century

Sat, 03 Nov 2012 19:34:33 -0400

I had my one, and only, pituitary surgery on this date in 1987. Of course, I was trying to get a diagnosis for several years before that.

I know it's hard to get a diagnosis now - imagine how hard it was over 30 years ago - before the Internet, Facebook, Twitter, message boards, chatrooms. No online support - no support anywhere.

Adrenal Insufficiency - Female Patient found Unconscious with Syringe Nearby

Wed, 31 Oct 2012 20:59:29 -0400

Adrenal Insufficiency (AI) is a life-threatening in which the body is unable to produce enough cortisol to sustain life. In other words, their adrenal cortex is “asleep.” People suffering from AI take daily cortisol/glucocorticoid steroid replacement because whatever adrenal function is depleted. These patients are glucocorticoid dependent. In times of injury, dehydration, illness or surgery, they require an injection of Solu-Cortef. Solu-Cortef contains both glucocorticoid and mineralocorticoid properties, helping the body to compensate during a stress event.

Use of ketoconazole in the treatment of Cushing's syndrome

Tue, 30 Oct 2012 08:56:01 -0400

The therapeutic value of ketoconazole for long term treatment of patients with Cushing's syndrome was studied. Seven patients with Cushing's disease and one with an adrenal adenoma received 600-800 mg/day ketoconazole for 3-13 months.

Blog Post: Cushing's, The "Gift" that Keeps on Giving

Tue, 09 Oct 2012 10:45:23 -0400

I had an eye doctor appointment yesterday. No problems, just a routine check, maybe update my contacts to a newer version.

I was completely not ready when the doctor said “cataracts” to me…

Novartis launches pasireotide for Cushing’s disease

Tue, 02 Oct 2012 05:53:16 -0400

Cushing’s disease patients for whom surgery is not a viable option have a new treatment alternative, in the form of the orphan medicine pasireotide.

Dr. Amir Hamrahian Answered Our Questions About Cushing's and Korlym

Tue, 02 Oct 2012 00:51:52 -0400

October 1, 2012 at 6:30 PM eastern, Dr. Amir Hamrahian answered our questions about Cushing's, pituitary or adrenal issues and Korlym (mifepristone) in BlogTalkRadio.

Archives are available now.

Transsphenoidal Microsurgery for Cushing’s Disease: Initial Outcome and Long-Term Results

Thu, 27 Sep 2012 09:50:57 -0400

Untreated Cushing’s disease and the resultant chronically elevated glucocorticoid levels lead to severe metabolic disturbances, including diabetes mellitus, obesity, hypertension, muscle wasting, and osteoporosis.

Cushie warriors: men, women & children who battle Cushing's numerous times in hopes of winning the war

Thu, 27 Sep 2012 08:54:19 -0400

Page is being updated. Last update 9/27/12

Helpful Doctor Updated

Fri, 14 Sep 2012 08:42:12 -0400

Richard J. Auchus, M.D., Ph.D. has moved from Texas to Michigan

Efficacy and Safety of Pasireotide Administered Monthly in Patients With Cushing's Disease

Fri, 07 Sep 2012 19:23:28 -0400

A Randomized, Double-blind, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of Pasireotide LAR in Patients With Cushing's Disease

We have started the Non-Profit Paperwork

Wed, 25 Jul 2012 09:26:53 -0400

As of July 24, 2012: Corcept will send us the proceeds of the "Clicking Campaign" as soon as we submit our tax ID to them. The process has begun to get that tax ID AND our non-profit organization finalized.

Cushing's Expenses Spreadsheet

Mon, 08 Oct 2012 11:09:26 -0400

Where do my donations go? Updated July 25, 2012.

Cushing's Help Turned Twelve During the Conference!

Mon, 23 Jul 2012 17:47:30 -0400

Twelve years ago I was talking with my dear friend Alice, who runs a wonderful menopause site, Power Surge, wondering why there weren't many support groups online (OR off!) for Cushing's and I wondered if I could start one myself. We decided that I could.

This website (http://www.cushings-help.com) first went "live" July 21, 2000 and the message boards September 30, 2000. Hopefully, with this site, I’ve made some helpful differences in someone else's life.

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI

Thu, 28 Jun 2012 13:46:46 -0400

Excess endogenous glucocorticoids cause central obesity with an increased visceral to total fat ratio and this is associated with the metabolic syndrome and insulin resistance, increasing the cardiovascular risk.

Cushing's syndrome

Thu, 28 Jun 2012 13:38:28 -0400

Cushing's syndrome (CS) results from prolonged exposure to elevated endogenous cortisol. Majority of cases are caused by ACTH, pituitary, or ectopic origin. Primary adrenal hypersecretion is 15–20% caused by adenomas, carcinomas (ACC), and rarely by nodular adrenocortical disease. CS presents with all typical features.

New Helpful Doctor added

Thu, 28 Jun 2012 13:26:25 -0400

South Bend, Indiana

Our Locations

cushingshelp@gmail.com — Thu, 28 Jun 2012 13:39:07 -0400

Our Locations (Updated 6/28/12)
We Cushies are located all over the world - from 47 states and 54 countries and more are being added each day. 62 listings on the new MemberMap.

Genetic variant is linked to obesity and insulin resistance

Thu, 28 Jun 2012 11:12:19 -0400

Such excess exposure can result in weight gain, especially around the abdomen, as well as in disturbed blood sugar metabolism. This exposure most often occurs from long-term use of prednisone or other glucocorticoid medications, which are widely used to treat inflammatory diseases or to suppress the immune system. It also can result from endocrine diseases such as Cushing's syndrome. Cushing's causes overproduction in the body of the glucocorticoid cortisol, often called the "stress hormone."

Cortendo Receives Positive Orphan Drug Opinion from EMA for NormoCort for Cushing’s Disease

Wed, 27 Jun 2012 11:37:35 -0400

Cortendo Receives Positive Orphan Drug Opinion from EMA for NormoCort for Cushing’s Disease

Dr. Cargill Alleyne - Augusta, GA 2012 Best Doctors

Mon, 25 Jun 2012 18:52:27 -0400

The brain is the last frontier, rife with the potential for specialties and sub-specialties. Despite technological advances made since Dr. Harvey Cushing (1869-1939), the undisputed Father of Neurosurgery, pioneered effective operations, the organ of the brain still holds many mysteries. Young residents, believes Dr. Alleyne, have the advantage of flexible thinking and, thus, possess the power to not just practice neurosurgery competently, but to improve it.

Clinicopathological Correlations in Pituitary Adenomas

Sat, 16 Jun 2012 10:38:37 -0400

Pituitary adenomas are common neuroendocrine neoplasms arising from adenohypophysial cells. Recent progress in our understanding of pituitary tumorigenesis as well as pathways involved in molecular cytodifferentiation of the adenohypophysis has impacted on the classification of pituitary adenomas.

Printable Cushing's Brochure

Sat, 16 Jun 2012 09:25:34 -0400

The printable Cushing's Brochure has been updated. It is best printed out on tri-fold paper. This PDF is one page, front and back.

Medical management of Cushing's disease: what is the future?

Thu, 14 Jun 2012 14:03:59 -0400

Cushing's disease (CD) is caused by a corticotroph, adrenocorticotropic-hormone (ACTH)-secreting pituitary adenoma resulting in significant morbidity and mortality. Transsphenoidal surgery is the initial treatment of choice in almost all cases.

Updated Helpful Doctor: Alberta, Canada

Tue, 12 Jun 2012 17:22:38 -0400

A brilliant, resourceful, knowledgable, caring research doctor who has a team of endocrinologists equally as caring and knowledgable. I personnally believe I had the Best-of-the-BEST :) Thank you Dr. Chik.

Pasireotide in Cushing's Disease

Thu, 31 May 2012 14:27:16 -0400

In their study, Colao et al. (March 8 issue)1 examined the clinical efficacy and safety of two different doses of subcutaneous pasireotide in patients with newly diagnosed, persistent, or recurrent Cushing's disease. Since alternative therapies (including bilateral adrenalectomy) are available for patients with persistent or recurrent Cushing's disease, it would be important to consider all options before embarking on what might turn out to be many years of medication.

Correlation Between Histological Subtypes and MRI Findings in Clinically Nonfunctioning Pituitary Adenomas

Wed, 30 May 2012 11:38:22 -0400

Correlation Between Histological Subtypes and MRI Findings in Clinically Nonfunctioning Pituitary Adenomas

Adrenal cavernous hemangioma with subclinical Cushing's syndrome: report of a case

Wed, 30 May 2012 12:03:43 -0400

Subclinical Cushing’s syndrome was diagnosed preoperatively, as there was insufficient suppression of cortisol by low-dose dexamethasone, a low adrenocorticotropic hormone (ACTH) concentration, and diminished ACTH and cortisol circadian rhythms without the typical clinical manifestation and symptoms of hypercortisolism.

Course of pregnancies in women with Cushing’s disease treated by gamma-knife

Wed, 16 May 2012 13:39:46 -0400

Data concerning pregnancy in women with Cushing’s disease treated by gamma-knife (GK) are scanty. We present and discuss the course and outcome of five pregnancies in two women with Cushing’s disease (CD), the first of whom was treated only by GK, and the second one treated by surgery, GK and ketoconazole.

Psychological Manifestations of Pituitary Disease

Fri, 04 May 2012 14:25:55 -0400

It is well recognized that depression and anxiety are present in many patients with hyperprolactinemia and Cushing’s disease. Personality change and anxiety are commonly seen in patients with acromegaly and hypopituitarism. There are several options for treatment, both pharmacological and psychological. One element that is unfortunately ignored in this illness is the effect on the family. Effective treatment of the patient with pituitary disease included treatment of the family.

Personal Narrative: Battling Cushing's Disease

Fri, 04 May 2012 14:01:46 -0400

Those four, heart-wrenching words hitting me like a ton of bricks: “You have Cushing's Disease.” “What?” I exclaimed. “Cushing's? Are you serious? Me, a disease? Am I going to die?” These were all questions I managed to throw at the doctor in between ...

Regeneration of the human pituitary

Wed, 02 May 2012 22:27:32 -0400

The pituitary remnant was examined in 13 patients in whom a stereotaxic, transsphenoidal, high-frequency coagulation had been performed because of widespread metastatic disease. The patients were divided in three groups according to the state of regeneration of pituitary tissue. The first group (patients dying 3 to 7 days after surgery) showed only signs of acute necrosis. The second group (patients dying 24 to 219 days after surgery) demonstrated mitotic figures and regenerated areas in the adenohypophysis. The third group (patients dying 252 to 353 days after surgery) showed no mitoses but large areas of regenerated glandular cells as a sign of completed regeneration. It seems that the pituitary can regenerate provided that the dominating hypothalamic centers remain undamaged during hypophysectomy

Do you believe that your Cushing’s syndrome is related to your service in the military?

Wed, 02 May 2012 13:18:26 -0400

Do you believe that your Cushing’s syndrome is related to your service in the military? At Morgan & Weisbrod, we can review your medical records and help you collect evidence that connects your illness to your service. If your illness was a result of your active duty, you could deserve veterans’ disability benefits.

MEN1 and pituitary adenomas

Wed, 02 May 2012 13:12:28 -0400

MEN1 gene mutations predispose carriers to pituitary tumors. Molecular pathways involved in the development of these tumors seem different to what is known in sporadic tumors. Clinical studies showed that all types of adenomas can be found with a predominance of prolactinoma and macroadenoma compared to a control population.

Cushing's Disease and Idiopathic Intracranial Hypertension

Wed, 02 May 2012 13:04:30 -0400

A 33-year-old woman with Cushing’s disease underwent successful surgical resection of a pituitary adenoma and developed IIH 11 months later after inadvertent withdrawal of oral glucocorticoids.

Pituitary Hormone Deficiency in Women

Wed, 02 May 2012 12:46:18 -0400

A deficiency in some of the pituitary hormones can be replaced with medications. Thyroid hormone can be replaced in thyroid hormone deficiencies, adrenal deficiencies can be treated with hydrocortisone, or cortisol replacements. And if a women loses reproductive function those can be replaced with estrogen/progesterone combinations. If fertility is an issue a neuroendocrinologist may work in conjunction with reproductive endocrinologists and OB/GYN to help fertility induction.

Kind Words of Thanks

Wed, 02 May 2012 11:18:02 -0400

Latest: Im sure you get this all the time but thank you for this web site!! When I had lymphoma stage 4 there was all kinds of info and support and so much understanding. Cushings has been a completely different journey very little understanding from Doctors and almost 0 from general public so thankful for this site. Hope you are doing well. And again thank you.

Updated: Maryland: Johns Hopkins Pituitary Tumor Center

Wed, 25 Apr 2012 12:15:35 -0400

The Pituitary Tumor Center's physicians and allied practitioners work together to develop a comprehensive diagnostic and treatment plan individualized for each patient's unique condition and symptoms. Our goal is to provide optimal care and to minimize the traveling of our patients. In most cases, appointments with all the specialists are scheduled on the same day.

Novartis drug Signifor approved in the EU as the first medication to treat patients with Cushing's disease

Wed, 02 May 2012 12:48:33 -0400

Signifor (pasireotide) is approved in the European Union (EU) for the treatment of adult patients with Cushing's disease for whom surgery is not an option or for whom surgery has failed. For the treatment of Cushing's disease, Signifor has been studied as a twice-daily subcutaneous (sc) injection and is currently being evaluated as a long-acting release (LAR), once-monthly intramuscular (IM) injection as part of a global Phase III program. Signifor is a multireceptor targeting somatostatin analog (SSA) that binds with high affinity to four of the five somatostatin receptor subtypes

Magic Foundation Cushing's Conference

Sat, 21 Apr 2012 12:52:55 -0400

Includes: Adult Growth Hormone Deficiency, Panhypopituitarism, Cushings and Acromegaly, July 19-22, 2012, Chicago, Illinois

New Comment on Day Twenty, Cushing's Awareness Challenge

Fri, 20 Apr 2012 18:27:48 -0400

Mrs. Fight commented on Day Twenty, Cushing's Awareness Challenge - Cushie Info:

So very true about it "being our only shot". After being learning I had Cushing's and then later learning all about it thanks to Cushing's Help and the support of my fellow "Cushies". My husband and I have often talked about how the doctors will have lots of patients and if they get it wrong and one of us slip through the cracks they have a new patient in the waiting room the next day. Our families are left wondering why we are no longer here.

The value of knowing about what you have enables you to understand the process, communicate more effectively, participate with knowledge, ask questions, select options for care that are right for you, helps you to explain the condition to those you love or care about and it gives you some small (very small) sense of control over your life instead of being completely overpowered by the illness (any illness).

As always thanks Mary O for giving all of us so much!

Day Twenty, Cushing's Awareness Challenge

Fri, 20 Apr 2012 18:29:32 -0400

This one is so easy. I've said it a thousand times - you know your own body better than any doctor will. Most doctors have never seen a Cushing's patient, few ever will in the future.

If you believe you have Cushing's (or any other rare disease), learn what you can about it, connect with other patients, make a timeline of symptoms and photographs.

New Emergency Letter for Adrenal Insufficiency

Thu, 19 Apr 2012 13:33:00 -0400

Thanks to Prof Hindmarsh and Kathy Geertsma for making this happen. Download it and write in your personal information. Keep it in with you!

Day Nineteen, Cushing's Awareness Challenge

Thu, 19 Apr 2012 11:39:30 -0400

In Day 10 on April 10, 2012, I wrote about how we got the Cushing's colors of blue and yellow. This post is going to be about the first Cushing's ribbons.

Day Eighteen, Cushing's Awareness Challenge

Thu, 19 Apr 2012 11:39:25 -0400

I'll never know if that hit on my head contributed to my Cushing's but I have seem several people mention on the message boards that they had a traumatic head injury of some type in their earlier lives.

Day Seventeen, Cushing’s Help Challenge

Thu, 19 Apr 2012 11:38:42 -0400

Way back when we first got married, my husband thought we might have a lot of kids. He was from a family of 6 siblings, so that's what he was accustomed to. I am on only child so I wasn't sure about having so many...

Day Sixteen, Cushing’s Awareness Challenge

Mon, 16 Apr 2012 10:54:42 -0400

But the amazing thing is this. My son had told me about a medication that was very similar to Provigil, that he had tried it while he was writing his doctoral thesis and it had helped him.
So, having tried the official doctor route and being rebuffed – again – I had decided to try this stuff on my own.

How I Became an E-Patient Through Cushing’s Disease

Mon, 16 Apr 2012 10:53:24 -0400

Thank you for sharing your story "How I Became an E-Patient Through Cushing's Disease" with us.
Its really quite remarkable and I'm sure will be a valued addition to our collection and help inform many people about Cushing's Disease.

New Helpful Doctor, Atlanta, GA

Sun, 15 Apr 2012 19:09:36 -0400

Carlos M. Isales, MD

Day Fifteen, Cushing’s Awareness Challenge

Sun, 15 Apr 2012 19:04:51 -0400

After I was finished with the Cushing’s long diagnostic process, surgery and several post-op visits to NIH, I was asked to give the scripture reading at my church. The man who did the sermon that week was the survivor of a horrific accident where he and his family were hit by a van while waiting at an airport.

Cushing's Awareness Challenge Bloggers

Mon, 16 Apr 2012 10:55:44 -0400

Over halfway through the challenge!

Day Fourteen, Cushing’s Awareness Challenge

Sat, 14 Apr 2012 22:00:25 -0400

And today, we talk about pink jeeps and ziplines…
How in the world did we get here in a Cushing’s Challenge? I’m sliding these in because in Day Twelve I linked (possibly!) my growth hormone use as a cause of my cancer – and I took the GH due to Cushing’s issues. Clear? LOL

Day Thirteen, Cushing’s Awareness Challenge

Sat, 14 Apr 2012 21:59:47 -0400

Butterflies are something else again. I like them because I would like to think that my life has evolved like a butterfly’s, from something ugly and unattractive to something a big easier on the eye.

Day Twelve, Cushing’s Awareness Challenge

Sat, 14 Apr 2012 21:57:19 -0400

Today’s Cushing’s Awareness Challenge post is about kidney cancer (renal cell carcinoma). You might wonder how in the world this is related to Cushing’s. I think it is, either directly or indirectly.

Day Eleven, Cushing’s Awareness Challenge

Sat, 14 Apr 2012 21:54:37 -0400

There were about 12 of us there [at NIH] and it was nice not to be alone with this mystery disease. Many of these Cushies (mostly women) were getting bald, couldn’t walk, having strokes, had diabetes. One was blind, one had a heart attack while I was there. Several were from Greece.

Day Ten, Cushing's Awareness Challenge

Sat, 14 Apr 2012 21:50:44 -0400

So, where did all this blue and yellow come from, anyway? The answer is so easy and without any thought that it will amaze you!

Stand Up and Be Counted!

Tue, 10 Apr 2012 01:05:56 -0400

For all Cushies, diagnosed or not, friends and family - add your name and whatever info you want to share to this map.

Day Nine, Cushing’s Awareness Challenge

Mon, 09 Apr 2012 22:22:15 -0400

Cushing’s Conventions have always been special times for me – we learn a lot, get to meet other Cushies, even get referrals to endos!
As early as 2001 (or before) my pituitary function was dropping. My former endo tested annually but did nothing to help me with the symptoms.

Google+ page for Cushings, updated daily

Mon, 09 Apr 2012 10:39:02 -0400

The new "official" page for Cushing's news here Google+. This is for sharing Cushing's news, info and support. Thanks!

Day Eight, Cushing’s Awareness Challenge

Sun, 08 Apr 2012 10:40:57 -0400

Dr. Cushing was born in Cleveland Ohio. The fourth generation in his family to become a physician, he showed great promise at Harvard Medical School and in his residency at Johns Hopkins Hospital (1896 to 1900), where he learned cerebral surgery under William S. Halsted

Day Seven, Cushing's Awareness Challenge

Mon, 09 Apr 2012 09:54:10 -0400

Sleep. Naps. Fatigue. I still have them all. I wrote on my bio in 1987 after my surgery "I am still and always tired and need a nap most days. I do not, however, still need to take whole days off just to sleep."

Pituitary Adenoma

Sat, 07 Apr 2012 12:01:20 -0400

Pituitary adenomas are uncommon, and are not cancers at all. They are almost always benign tumors that develop on the pituitary gland, found inside the skull just above the nasal passages. True pituitary cancers are called pituitary carcinomas, and are extremely rare.

Day Six, Cushing’s Awareness Challenge

Fri, 06 Apr 2012 09:15:54 -0400

People sometimes ask me how I found out I have Cushing’s. Theoretically, it was easy. In practice, it was very difficult.
In 1983 I came across a little article in the Ladies Home Journal which said “If you have these symptoms…”

Remission of Cushing’s disease may improve body composition, reduce cardiovascular risk markers

Thu, 05 Apr 2012 13:33:31 -0400

Patients in remission of Cushing’s disease may experience decreased total fat and improved cardiovascular risk factors, according to data from a prospective study.

Day Five, Cushing’s Awareness Challenge

Thu, 05 Apr 2012 13:13:04 -0400

The top image is the official Cushing’s path to a diagnosis but here’s how it seems to be in real life...

Day Four, Cushing's Awareness Challenge

Wed, 04 Apr 2012 02:43:48 -0400

The Seven (only 7???) Dwarves of Cushing's

Day Three, Cushing's Awareness Challenge

Tue, 03 Apr 2012 20:17:48 -0400

For all of my early life, I was the good, compliant, patient. I took whatever pills the doctor prescribed, did whatever tests h/she (most always a he) wrote for. Believed that whatever he said was the absolute truth. He had been to med school. He knew what was wrong with me even though he didn’t live in my body 24/7 and experience what I did...

Dr. Theodore Friedman Returned April 2, 2012

Mon, 02 Apr 2012 21:47:33 -0400

Have questions about thyroid issues?
Listen to the archived interview.

Do We Feel Bad for the Drug Reps?

Mon, 02 Apr 2012 21:46:38 -0400

Only 5 days Left to Support Cushing's ...With A Click

Sat, 14 Apr 2012 21:55:00 -0400

It is difficult to evaluate the recurrence and progression potential of pituitary adenomas at presentation. The World Health Organization classification of endocrine tumors suggests that invasion of the surrounding structures, size at presentation, an elevated mitotic index, a Ki-67 labeling index higher than 3%, and extensive p53 expression are indicators of aggressive behavior.

Day Two, Cushing’s Awareness Challenge

Mon, 02 Apr 2012 12:34:31 -0400

I would be remiss if I didn’t use today’s Challenge post to remind readers that there is a wonderful opportunity to ask Dr. Theodore Friedman questions about thyroid or other issues. Dr. Friedman (or Dr. F, as he is called on the boards) has been a help to so many Cushies. He specializes in cyclical Cushing’s and seems to be able to diagnose what other, lesser, doctors cannot.

Day One, Cushing’s Awareness Challenge

Sun, 01 Apr 2012 07:09:48 -0400

How fitting that this challenge should begin on April Fool’s Day. So much of Cushing’s Syndrome/Disease makes us Cushies seem like we’re the April Fool. ...

In Memory Of Natalie Fay

Sat, 31 Mar 2012 11:25:58 -0400

Updated with a new donation in Natalie's memory

Cushie Bloggers

Wed, 28 Mar 2012 12:01:29 -0400

Our Newest Cushie Blogger is Missaf: Brain Tumors Can Make You Fat

Since April 8th is the day we Cushing's patients call "Cushing's Awareness Day," I'd like to do my part by blogging as much as possible throughout the month of April on this blog.

Alicia: Hear hoofbeats, think Zebras

This is a blog, loosely based, on my experiences with Cushing's Disease; illness, recovery, and what lies between. It is more of a place where I can ramble on about what is on my mind, in the hopes of clearing my mind enough that I might sleep tonight.

Cushing's Awareness Challenge

Mon, 26 Mar 2012 22:38:51 -0400

Do you blog? Want to get started?

Since April 8 is Cushing's Awareness Day, several people got their heads together to create this blogging challenge.

All you have to do is blog about something Cushing's related for the 30 days of April.

Cushing's Syndrome / Disease PDF files

Mon, 26 Mar 2012 09:24:38 -0400

This is a public collection - others with PDF files may add their Cushing's Syndrome / Disease PDF files

Single-Incision Transperitoneal Laparoscopic Left Adrenalectomy

Sat, 24 Mar 2012 11:36:14 -0400

Single-incision laparoscopic surgery (SILS) left adrenalectomy is a technically feasible and safe procedure in carefully selected patients. The definitive clinical, aesthetic and functional advantages of this technique require further analysis.

New drug shows promise in patients with rare illness

Sat, 24 Mar 2012 00:47:04 -0400

Until now, surgery and radiotherapy have been the only options for many patients. However, a drug developed by Novartis Pharmaceuticals has been found to act on the tumours, cutting cortisol levels an average of 50 per cent.

The March 18, 2012 Cushing's Newsletter is out

Sun, 18 Mar 2012 06:16:34 -0400

Occasional Newsletters are Back: Members of cushie.info will automatically receive these occasional newsletters. Of course, you may opt-out at any time. Thank you for your interest. Non-members may subscribe.

We Have Lost Another Cushie.

Sun, 18 Mar 2012 02:34:40 -0400

"Often misdiagnosed, Cushing's is associated with a broad range of health problems – causing physical changes, metabolic abnormalities and emotional difficulties – and if not controlled, significantly increases patients' risk of dying much younger than expected."

Experimental drug reduces cortisol levels, improves symptoms in Cushing's disease

Fri, 16 Mar 2012 08:57:43 -0400

A new investigational drug significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease in the largest clinical study of this endocrine disorder ever conducted.

Retroperitoneal Adrenal-Sparing Surgery for the Treatment of Cushing's Syndrome Caused by Adrenocortical Adenoma: 8-Year Experience With 87 Patients

Thu, 15 Mar 2012 12:17:12 -0400

The retroperitoneal approach is reliable and safe for treating Cushing’s syndrome. The laparoscopic technique can decrease the prevalence of intraoperative complications. Retroperitoneal laparoscopic partial adrenalectomy can be performed with extremely low morbidity and achieves an excellent outcome, although death may occur during the postoperative period in high–risk patients. Postoperative management plays an important role in the surgical treatment of Cushing’s syndrome.

Diagnosis - Cushing's Syndrome

Wed, 14 Mar 2012 11:16:58 -0400

Until recently, the patient was in good health for her age, with only a few medical problems: high blood pressure, which was controlled with one medication; hypothyroidism, treated with Synthroid; and cataracts, which had been surgically repaired. Now, out of the blue, she was experiencing rapid weight gain, swelling and weakness in her legs, which made it hard to walk.

Adrenal insufficiency following bariatric surgery

Wed, 14 Mar 2012 10:08:57 -0400

We describe for the first time in the literature the unexpected finding of adrenal insufficiency following a bilo-pancreatic diversion (BPD)

The Adrenal Vein Sampling International Study (AVIS) for Identifying the Major Subtypes of Primary Aldosteronism

Tue, 13 Mar 2012 03:44:00 -0400

In patients who seek surgical cure of primary aldosteronism (PA), The Endocrine Society Guidelines recommend the use of adrenal vein sampling (AVS), which is invasive, technically challenging, difficult to interpret, and commonly held to be risky.

Cushing's Awareness Day is coming - April 8, 2012

Sun, 11 Mar 2012 12:26:04 -0400

Cushing's Awareness Day ideas

Books!

Sun, 11 Mar 2012 12:23:56 -0400

Many helpful books are prohibitively expensive, so you may want to check them out of the library, if possible. I found these from amazon.com interesting.

Other Diseases

Thu, 08 Mar 2012 12:32:12 -0500

Information added to Carney Complex

A 12-Month Phase 3 Study of Pasireotide in Cushing's Disease

Thu, 08 Mar 2012 12:21:48 -0500

In this double-blind, phase 3 study, we randomly assigned 162 adults with Cushing's disease and a urinary free cortisol level of at least 1.5 times the upper limit of the normal range to receive subcutaneous pasireotide at a dose of 600 μg (82 patients) or 900 μg (80 patients) twice daily

New Study to Treat Cushing's disease

Thu, 08 Mar 2012 12:00:59 -0500

Cushing's disease is associated with central obesity, osteoporosis, arterial hypertension, insulin resistance, glucose intolerance, diabetes mellitus, dyslipidemia, cardiovascular disease, and increased mortality. The next line of defense after surgery is to try radiation therapy, bilateral adrenalectomy, and medical therapy, but doctors are now looking at something new.

New pituitary specific treatment for Cushing’s

Thu, 08 Mar 2012 11:14:03 -0500

An investigational somatostatin analogue has significantly reduced elevated cortisol levels in patients with Cushing’s disease, researchers report.

Of 103 patients, 61 had a ‘substantial reduction’ (≥50%) in urinary free cortisol level at month six, the randomised double blind phase 3 trial found.

How Reddit saved this Cushie's life

Thu, 08 Mar 2012 10:51:43 -0500

An active athlete who ran San Francisco's Bay to Breakers marathon in an hour, he started getting strange symptoms including rapid weight gain and high blood pressure. A doctor couldn't diagnose what was going on.

New Helpful Doctor added to Orlando, Florida

Tue, 06 Mar 2012 05:58:54 -0500

Endocrinologist Dr. Jyothi Joseph-Hayes

Experimental Drug Shows Promise Against Cushing's Disease

Thu, 08 Mar 2012 11:43:13 -0500

An experimental drug called pasireotide reduced levels of the "stress hormone" cortisol and improved symptoms in patients with Cushing's disease, a new study found.

Cushing's disease is a rare (three to five cases per million people) hormonal disorder that causes a wide range of health problems and, if untreated, significantly increases a patient's risk of dying at a much younger age than normal, researchers said in a news release.

For Cushing's: Tosoh Bioscience Launches the ST AIA-PACK DHEA-S Assay

Wed, 07 Mar 2012 18:27:21 -0500

ST AIA-PACK DHEA-S is designed for In Vitro Diagnostic Use Only for the quantitative measurement of dehydroepiandrosterone sulfate (DHEA-S) in human serum, heparinized or EDTA plasma. DHEA-S is used for the diagnosis of various diseases of the adrenal cortex, and is especially useful for the differential diagnosis of Cushing's syndrome.

Small cell carcinoma of the vagina causing Cushing's syndrome by ectopic production and secretion of ACTH

Mon, 05 Mar 2012 11:59:36 -0500

This case report establishes a clinical association between vaginal small cell carcinoma and ectopic Cushing's syndrome, confirming the neuroendocrine potential of this malignancy and features common to small cell neoplasms originating in other sites.

Cushing's: A Numbers Game

Wed, 29 Feb 2012 11:55:13 -0500

Trisha Thaens compiled this very moving video of her Cushing's journey. She says "OK, here is the link. I think it is best watched in full screen. I wasn't going to share quite yet, but was asked to because its Rare Disease Day."

Success Stories! (Updated 2/20/12)

Mon, 20 Feb 2012 10:10:49 -0500

Good news is always nice to read.

Brochures for Primary Care Physicians, to increase awareness of Cushing's syndrome. In English and Spanish

Wed, 15 Feb 2012 10:59:39 -0500

The Spanish version is much larger and takes longer to load.

Videos of interest to Cushing's Patients Updated 2/15/12

Wed, 15 Feb 2012 09:24:22 -0500

Added 2 new videos

Making sense of your child's health numbers

Wed, 15 Feb 2012 08:51:50 -0500

For example, patients who have a higher concentration of fat in the neck and head region could have Cushing's syndrome, and those who are relatively short for their weight and age and have other symptoms might have low thyroid function.

Clinical relevance of cardiac structure and function abnormalities in patients with Cushing's syndrome before and after cure

Wed, 15 Feb 2012 08:48:11 -0500

Cushing's syndrome is associated with an increased risk for abnormalities of cardiac mass, which ameliorates, but does not fully disappear after remission. Systolic and diastolic functions are largely within the normal range in these patients.

New Endocrinology App

Mon, 06 Feb 2012 19:02:48 -0500

This app includes topics such as Cushing's disease, diabetic ketoacidosis, managing acute type I and type II diabetes, hypercholesterolemia, adrenal insufficiency, hyperthyroidism, thyroid storm, and much more. Key facts are presented in tables and flow-charts to allow quick reference to crucial information.

Two New Donation Services

Wed, 01 Feb 2012 16:27:58 -0500

When I started Cushings-Help.com, it was my intention to make it a place for all to receive much needed free help and support. That is still my intention; however, these costs keep mounting, so you now have the option of making a donation to help with the running of these websites. If you are satisfied with our support, information and/or the help you receive here, please consider making a donation. Your donation will help to offset the costs of keeping these sites online and free to all who need them.

To register and participate in any of the Cushing's Help and Support websites and services is free. However, it is through the generosity of our members that these sites remains free. Members who choose to "subscribe" or "donate" help keep the website fees paid so that the thousands of members can enjoy the support offered.

Your donation helps with the upkeep of the many sites in the Cushing's Help family, cushie.info, cushings-help.com, cushings-support.com, cushings-info.com, cushingsonline.com, addisons-help.com, the message boards, podcasts, Voice Chats/Interviews, CushieWiki, blogs, Facebook, chats, blogs and much more.

In addition to PayPal, you may also now use https://www.dwolla.com/u/812-616-4967 or https://www.wepay.com/donate/cushings instead.

Thanks for your support!

Pituitary Disease: Posterior Pituitary

Fri, 20 Jan 2012 14:45:50 -0500

Diabetes insipidus (DI) occurs when patients are missing the major water-retaining hormone in their body, antidiuretic ...

Novartis drug Signifor® recommended by CHMP for EU approval to treat patients with Cushing's disease

Fri, 20 Jan 2012 13:14:38 -0500

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion for Signifor® (SOM230, pasireotide) for the treatment of Cushing's disease. There are currently no approved medicines in the European Union (EU) targeting Cushing's disease, a debilitating endocrine disorder caused by excess cortisol in the body due to the presence of a non-cancerous pituitary tumor.

New Video Forum on Cushings Help Community Message Boards

Fri, 20 Jan 2012 12:49:22 -0500

Videos from YouTube and elsewhere of interest to the Cushing's Community

Pregnancy-induced Cushing's Syndrome: A Case Report

Thu, 19 Jan 2012 05:06:32 -0500

Cushing's syndrome(CS) during pregnancy is a rare condition with fewer than 150 cases reported in the literature.

First potential Prader-Willi treatment among EMA's orphan recommendations

Fri, 20 Jan 2012 11:40:18 -0500

Laboratoire HRA Pharma's ketoconazole for treatment of Cushing's syndrome.

Treatment Options in Cushing's Disease

Thu, 19 Jan 2012 04:49:38 -0500

The aim of this review is to analyze and present current treatment options in Cushing's disease.

The Toxicologist Today: New origin(?) and New methodology(!) - Reassessing Cushing's Syndrome.

Thu, 19 Jan 2012 04:15:41 -0500

A new method for measuring cortisol in Cushing's syndrome patients. Length of exposure to glucocorticoids define how harsh Cushing's can be, thus representing a fine indicator for endocrinologists.

GH replacement therapy associated with development of diabetes

Thu, 19 Jan 2012 03:52:11 -0500

The incidence of diabetes was increased in patients with growth hormone deficiency who were on growth hormone replacement therapy, according to researchers in Europe.

A New Link in the Stress Response Could Mean Better Treatment Soon

Mon, 02 Jan 2012 18:17:57 -0500

The stress cascade is governed by the brain's hypothalamus, which communicates with the pituitary and adrenal glands, which in turn secrete stress hormones like cortisol. Disruptions in this pathway are also connected with problems like postpartum depression, obesity, Cushing's syndrome (hypercortisolism), premenstrual syndrome (PMS), epilepsy, and osteoporosis, according to the study's press release.

Steroid converter

Thu, 12 Jan 2012 12:02:22 -0500

Corticosteroids conversion calculator (hydrocortisone, dexamethasone, prednisone, methylprednisolone, betamethasone and more)

(Adrenal Cushing's) Tumour behind 7-yr-old's weight gain, moustache

Tue, 10 Jan 2012 12:15:07 -0500

Tanzania resident Mohammad Abdulrazaq Jussa recuperating after city doctors removed 7-cm tumour from his adrenal gland, which was responsible for his 12-kg weight gain, growth of facial hair

Welcome! / Cushing-Help.com Support for Cushing's Syndrome and Cushing's Disease

Tue, 10 Jan 2012 11:32:25 -0500

Welcome to Cushing's Help and Support.

This site provides information, support, news, and education for people with Cushing's or other endocrine problems, their friends and families.

Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of cortisol. Cushing's is a debilitating disease which causes the overproduction of cortisol, the substance that regulates blood pressure, and the metabolism of proteins, carbohydrates and fats. Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. It can be caused by a tumor of the pituitary gland, adrenal gland, elsewhere in the body (ectopic) or by excessive steroid use.

This website deals with Thyroid Disorders, Addison's Disease, Adrenal Disorders, Cushing's Syndrome, Pituitary Disorders, Pituitary disease, Growth Hormone, Pheochromacytomas, Fibromyalgia, Chronic Fatigue Syndrome, Hormone and Gland Disorders, Conn's Disease, Hyperaldosteronism, High Blood Pressure, Hypertension, Diabetes, Sheehan's Syndrome, Men1, Acromegaly, Nelson's Syndrome, PCOS, PPNAD, Arthritis, Bipolar Disorder, Headaches, Autoimmune Diseases, PTU, Cortisol, ACTH, and Thyroid Antibodies. This page includes Cushing's News, Events, Clinical Trials, Bios, information on the new RSS Feeds and much more.

What is the best long-term management strategy for patients with primary adrenal insufficiency?

Wed, 04 Jan 2012 18:29:52 -0500

This article provides answers to the important daily clinical questions, such as correct dose finding, dose adaptation in special situations, e g, pregnancy, improvement of quality of life and measures for protection from adrenal crisis. Other important aspects discussed are side effects of glucocortiocid replacement therapy and interactions with other drugs.

Synchronous bilateral adrenalectomy by midline incision: A reliable method for treatment of hypercortisolism

Wed, 04 Jan 2012 18:12:26 -0500

Bilateral adrenalectomy via a midline incision is a promising and acceptable technique for patients with Cushing syndrome. However, due to excess adipose tissue and lack of enough exposure, adrenalectomy by lumbotomy in such patients has prominent limitations. Therefore, midline incision provides feasible exposure for direct visualization of both adrenals.

Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis.

Mon, 02 Jan 2012 18:06:41 -0500

CLP-induced sepsis resulted in dynamic changes of ACTH, corticosterone and aldosterone levels. In addition, electrolyte levels showed significant disturbances following CLP. These electrolyte perturbations might be evoked by a downstream effect or a dysfunctional HPA-axis response during sepsis and contribute to severe complications during sepsis.

Red alert: Hypertension on the prowl

Sun, 01 Jan 2012 14:44:33 -0500

Secondary hypertension– some additional signs and symptoms suggest that the hypertension is caused by disorders in hormone regulation. Hypertension combined with obesity distributed on the trunk of the body, accumulated fat on the back of the neck (“buffalo hump”), wide purple marks on the abdomen (abdominal striae), or the recent onset of diabetes suggests that an individual has a hormone disorder known as Cushing’s syndrome. Hypertension caused by other hormone disorders such as hyperthyroidism, hypothyroidism, or growth hormone excess will be accompanied by additional symptoms specific to these disorders.

Criteria for Online Support Group

Sun, 01 Jan 2012 13:27:27 -0500

I am a nurse practitioner student and I need your help. I am trying to develop a set of criteria to give to my patients to help them find an on-line support group. I want to find out what on-line support group users like or dislike about on-line support and what you look for in a good group.

Complications of endoscopic surgery of the pituitary adenomas: analysis of 570 patients and review of the literature

Sat, 31 Dec 2011 12:39:14 -0500

The complication rates observed in the study suggests that the endoscopic pituitary surgery is at least as safe as microscopic transphenoidal surgery. These rates were obtained with due experience and well–coordinated teamwork. To further improve these rates, new technological developments will be helpful.

Investigational drugs may expand medical treatment of Cushing's syndrome

Thu, 22 Dec 2011 18:53:06 -0500

Currently, endocrinologists use several medical therapies to treat hypercortisolism, although none have FDA approval for that particular indication. Two new investigational drugs — mifepristone (Korlym, Corcept Therapeutics) and pasireotide (SOM230, Novartis) — have the potential to meet those unmet needs

Subclinical Cushings syndrome: definition and management

Thu, 22 Dec 2011 18:53:47 -0500

The management of subclinical Cushing's syndrome, that remains a highly debated issue, is also addressed and discussed. Most of the recommendations made in this chapter reflects the view and the clinical experience of the Authors and are not based on solid evidence.

A Pill That Stops Stress In Your Brain Before You Feel It

Fri, 16 Dec 2011 09:34:43 -0500

Stress makes many of us miserable — but it can also kill you. Besides just causing horrible anxiety and depression, the physiological basis for stress has also been linked to diseases as varied as obesity, postpartum depression, Cushing's syndrome, epilepsy, and osteoporosis.

P36 - Severe Osteoporosis in Cushing’s Syndrome

Wed, 14 Dec 2011 21:20:23 -0500

This case underlines the importance of a correct diagnostic and therapeutic approach in patients with severe osteoporosis. Over time, we will evaluate the efficacy of the treatment in preventing new fractures and the whether the use of a bone anabolic agent might be the correct choice also in order to control pain and improve quality of life. There are no reports in the literature of patients with Cushing’s syndrome treated with teriparatide.

Do patients with Type 2 Diabetes Mellitus have an increased prevalence of Cushing's Syndrome?

Wed, 14 Dec 2011 06:22:02 -0500

Many clinical features are common for patients with Type 2 Diabetes Mellitus (T2DM) and Cushing's Syndrome (CS) such as central obesity, hypertension and dyslipidaemia. Patients with CS often have T2DM. Since T2DM is much more frequent than CS it is possible that some patients with T2DM have increased production of cortisol and thus represent patients with CS.

Cushing's Syndrome Clinical Analysis of 77 Cases

Sat, 10 Dec 2011 14:38:51 -0500

OBJECTIVE To analyze the cause of Cushing's syndrome classification, the major clinical manifestations and laboratory features of frequency of occurrence, and the efficiency of various diagnostic methods to evaluate the clinical doctors to improve diagnosis and treatment of disease, improve patient prognosis.

An Artistic Triumph Over Cushing's Disease: J. Jordan Bruns

Fri, 09 Dec 2011 15:21:11 -0500

Destruction and rebirth are two common themes in the paintings and drawings of Glen Echo Park's resident artist, Jordan Bruns... and for good reason. The 29-year-old survived a rare form of Cushing's disease, and underwent a surgery for $1 million at the National Institutes of Health to remove a tumor lodged behind his eyes. Rebecca Sheir visits Bruns' studio in Glen Echo's Stone Tower, to hear about the artist's battle with the incurable disease, and how it's affected his art.

Book: Harvey Cushing: A Life In Surgery

Fri, 09 Dec 2011 13:50:09 -0500

This is the definite Cushing biography, an epic narrative of high surgical adventure, capturing the highs and lows of an extraordinary life.

Adrenal glands: The reserve tank for stress?

Fri, 09 Dec 2011 13:24:00 -0500

Have you ever noticed that when you are "stressed" you can feel either emotionally/physically depleted or energized? When our body is under stress the brain responds by producing epheniphrine (aka adrenaline), sending signals to our adrenal glands, increasing the rate at which our heart beats while releasing oxygen to our muscles. The long term response to this process produces cortisol (aka the stress hormone) facilitating the release of energy throughout our body. However, when our body isn't properly balanced these hormones can wreak havoc on our wellness possibly resulting in one of three conditions: Cushing's syndrome, Cushing's disease or Addison's disease.

Overt immune dysfunction after Cushing's syndrome remission: a consecutive case series and review of the literature

Tue, 06 Dec 2011 13:27:45 -0500

Autoimmune diseases frequently improve during active Cushing's syndrome. Several studies have reported new onset or exacerbation of these conditions upon cortisol normalization.

Video - Cushing's Disease Misdiagnosis (Sharmyn)

Tue, 06 Dec 2011 12:49:37 -0500

Misdiagnosed for seven years, Sharmyn takes control of her own health, finds the answers she's been searching for and a doctor that can help. Dr. Daniel Kelly, the Director of Saint John's Brain Tumor Center in Santa Monica, CA, successfully removes her tumor and gives her back her life.

Cushing's patient: She's pumped about winning, but not Punk'd

Mon, 05 Dec 2011 13:36:21 -0500

At first Woodward, who lives with the rare Cushing's disease, didn't know that she was the proud owner of a Nov. 18 Lotto Max ticket worth $1 million.

Pennsylvania Cushing's disease victim in need of goodwill

Mon, 05 Dec 2011 13:34:12 -0500

Allman's plight really began around 2005, when he was diagnosed with Cushing's disease.

People with Cushing's disease produce too much cortisol, a naturally occurring hormone that controls the body's use of carbohydrates, fats and proteins. This hyper-production of cortisol leads to weight gain. But it also weakens bones and muscles. So as a person with the disease gains weight, his or her body becomes less able to support it.

Have We Helped You?

Thu, 01 Dec 2011 09:35:17 -0500

When I started Cushings-Help.com, it was my intention to make it a place for all to receive much needed free help and support. That is still my intention; however, these costs keep mounting, so you now have the option of making a donation to help with the running of these websites. If you are satisfied with our support, information and/or the help you receive here, please consider making a donation. Your donation will help to offset the costs of keeping these sites online and free to all who need them.

To register and participate in any of the Cushing's Help and Support websites and services is free. However, it is through the generosity of our members that these sites remains free. Members who choose to "subscribe" or "donate" help keep the website fees paid so that the thousands of members can enjoy the support offered.

Your donation helps with the upkeep of the many sites in the Cushing's Help family, cushie.info, cushings-help.com, cushings-support.com, cushings-info.com, cushingsonline.com, addisons-help.com; the message boards, CushieWiki, podcasts, Voice Chats/Interviews, blogs, Secret Someone programs, Facebook, chats and much more.

These sites receive 97% of your donation through PayPal.

The Availability Of An Investigational Drug For Severe Cushing's Syndrome On a Compassionate Use Basis

Wed, 14 Dec 2011 12:26:03 -0500

Patients interested in using mifepristone should consult with their endocrinologist. Their endocrinologist, in turn, should contact Corcept for information about the compassionate use program. Please note that Corcept will provide information solely to physicians.

DH investigating suspected case of Cushing's syndrome with history of taking medicines prescribed by Chan Kwok-wing

Wed, 30 Nov 2011 13:10:21 -0500

The girl was found to have moon face, truncal obesity and recent weight gain.

Her clinical diagnosis was iatrogenic Cushing's syndrome. Cushing's syndrome can be caused by steroid overdose.

Endocrine disorders & female infertility

Wed, 30 Nov 2011 13:02:15 -0500

Acromegaly and Cushing’s disease may impair fertility at different levels, mechanisms involved however remain ill defined. Thyroid disorders, both hyperthyroidism and hypothyroidism, can interact with the ovaries, through a direct effect on ovarian function, but autoimmunity may be involved, as well as alterations of the sex hormone binding protein levels.

More Treatments for Cushing’s Disease

Tue, 22 Nov 2011 10:05:14 -0500

Cushing's disease...is caused by a tumor in the anterior pituitary gland that secretes excess amounts of adrenocorticotrophic hormone (ACTH). The only treatment is removal of the tumor, however, researchers have found a new treatment for these reoccurring tumors.

Full Endoscopic Transsphenoidal Surgery for Pituitary Adenoma-emphasized on Surgical Skill of Otolaryngologist

Sun, 20 Nov 2011 18:19:15 -0500

We removed pituitary adenoma in 28 patients via entirely endoscopic transsphenoidal approach with the help of special-designed instruments; we performed the procedure bloodlessly within limited time.

Acromegaly Community’s 2012 Conference

Fri, 18 Nov 2011 10:25:37 -0500

Keynote with a top endocrinologist, followed by discussion of the emotional issues of Acromegaly. After the overarching presentation, we will do breakout sessions for male patients, female patients, and a separate discussion just for loved ones, friends, and medical professionals. We will wrap up the day in a way that will help all people learn from the day.

Unveiling the Mysteries of Transsphenoidal Pituitary Surgery

Sun, 13 Nov 2011 16:51:50 -0500

A free webinar on November 18, 2011

Chocolate tower says thanks to hospice

Sun, 13 Nov 2011 16:48:12 -0500

Amy...is now struggling through thyroid cancer and Cushing’s syndrome.

(Addison's Disease) Coma man defies odds to write book

Sat, 12 Nov 2011 09:19:39 -0500

Addison’s disease is a rare disorder of the adrenal glands which are located on top of the kidneys. The condition affects the production of two hormones. Cortisol, which helps to regulate blood pressure, maintaining blood glucose and heart function. And aldosterone which also helps regulate blood pressure. Addison’s sufferers must get treatment if their blood pressure falls as it can be fatal.

Patients Diagnosed With Severe Adult GH Deficiency Using The Insulin Tolerance Test, Arginine Or Glucagon Stimulation Tests Share Similar Clinical Features

Thu, 10 Nov 2011 13:49:50 -0500

To determine whether the ITT, arginine (AST) and glucagon stimulation tests (GST) identify patients who have similar features of GH deficiency using a diagnostic threshold of 3 μg/l.

ACTH-secreting pituitary adenomas: size does not correlate with hormonal activity

Thu, 10 Nov 2011 13:37:32 -0500

ACTH-secreting pituitary adenomas (Cushing’s disease, CD) are the most frequent cause of Cushing’s syndrome. To test whether the size of ACTH-secreting adenomas correlates with the degree of biochemical and clinical features of hypercortisolism, we retrospectively reviewed all newly diagnosed CD patients seen at our institution by two neuro-endocrinologists over a 10-year time period. We documented the number of clinical manifestations and baseline hormonal measurements.

Diabetes in Cushing syndrome: basic and clinical aspects

Thu, 10 Nov 2011 13:17:01 -0500

Diabetes mellitus is a frequent complication of Cushing syndrome (CS) which is caused by chronic exposure to glucocorticoid excess, either endogenous or exogenous, and that is characterized by several clinical symptoms such as central obesity, purple striae, proximal muscle weakness, acne, hirsutism and neuropsychological disturbances.

DuoCort Pharma's Orphan Drug Plenadren® Granted European Marketing Authorization for Adrenal Insufficiency

Thu, 10 Nov 2011 13:12:33 -0500

The Swedish specialty pharma company, DuoCort Pharma, announced today that the European Commission has granted a European Marketing Authorisation for Plenadren®(hydrocortisone, modified release tablet), an orphan drug for treatment of adrenal insufficiency in adults, bringing these patients their first pharmaceutical innovation in over 50 years.
Developed by DuoCort Pharma, Plenadren® is a dual release hydrocortisone replacement therapy designed to better mimic the normal physiological cortisol profile in order to improve outcomes for patients suffering from adrenal insufficiency. Plenadren® is given as an oral tablet once daily. It has an outer layer releasing hydrocortisone immediately and an inner core releasing the rest of the drug more slowly during the day.

Endoscopic bilateral adrenalectomy (BLA) in patients with ectopic Cushing's syndrome

Thu, 10 Nov 2011 12:50:15 -0500

Bilateral adrenalectomy (BLA) is a treatment option to alleviate symptoms in patients with ectopic Cushing's syndrome (ECS) for whom surgical treatment of the responsible nonpituitary tumor is not possible. ECS patients have an increased risk for complications, because of high cortisol levels, poor clinical condition, and metabolic disturbances. This study aims to evaluate the safety and long-term efficacy of endoscopic BLA for ECS.

Hot Topics: Cushings Disease and Acromegaly

Thu, 10 Nov 2011 12:45:34 -0500

Information about how various treatments work in the body

Pituitary glands grown from mouse embryonic stem cells

Thu, 10 Nov 2011 12:44:38 -0500

If the same trick can be repeated for human pituitary glands it could transform the treatment of debilitating hormone disorders

What Is the Best Approach for the Evaluation and Management of Endocrine Incidentalomas?

Sat, 05 Nov 2011 14:14:44 -0400

Advances and more frequent use of diagnostic radiology have led to the increased prevalence of endocrine incidentalomas; Pituitary, thyroid, and adrenal incidentalomas must be assessed for dysfunctional hormone secretion and malignant potential; Inpatient management of endocrine incidentalomas should include consultation of endocrine or surgical teams in cases of dysfunctional or malignant lesions; Post-discharge instructions should clearly delineate timelines for repeat imaging, laboratory testing, and subspecialist follow-up.

Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of giant pituitary adenomas

Wed, 02 Nov 2011 18:25:24 -0400

Giant (>4 cm) pituitary macroadenomas often require surgery to decompress the optic nerves. Compared with traditional open or transsphenoidal microscopic methods, the extended endoscopic endonasal transsphenoidal approach offers the potential for aggressive resection via a minimal access corridor.

Doctors Use Google For Health Information, Too, Survey Finds

Wed, 02 Nov 2011 18:14:10 -0400

Maybe we shouldn't really be surprised to know that our doctors are Googling our medical problems.

A new survey by Wolters Kluwer Health shows that 46 percent of doctors frequently use sites like Google and Yahoo for treating, diagnosing or caring for their patients, The Atlantic reported…

…
In that study, doctors plugged three to five search terms into Google of 26 diseases that are notoriously hard to diagnose (including Cushing's syndrome and Creutzfeldt-Jakob disease).

Effects of Hormone Stimulation on Brain Scans for Cushing's Disease

Thu, 27 Oct 2011 13:21:47 -0400

Cushing's disease can be caused by a tumor of the pituitary gland, a small gland about the size of a pea located at the base of the brain. These tumors produce high levels of hormones, which cause obesity, diabetes, and growth problems. The cure for this type of Cushing's disease is to have surgery that removes the tumor but leaves the pituitary gland alone. Currently, magnetic resonance imaging scans are the best way to find these tumors. However, many of these tumors do not show up on the scan.

Steroid-induced Cushing's? The woman who aged from 23 to 73 in 'a few days'

Sat, 15 Oct 2011 14:15:29 -0400

Women are five times more likely to develop endogenous Cushing's syndrome than men, with most cases affecting people who are 25 to 40 years old.

Putting pituitary disease on the radar in Irish healthcare

Thu, 06 Oct 2011 13:27:06 -0400

The commencement of National Pituitary Awareness Week in Ireland provides a useful backdrop against which to write an article to highlight pituitary disease in this country. To many doctors, pituitary disease is relegated to the status of a side show of the greater endocrinology speciality.

Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences

Mon, 03 Oct 2011 12:15:46 -0400

Patients with classical pituitary apoplexy may show recurrent pituitary tumour growth and therefore these patients need continued post–operative surveillance if they have not had post–operative radiotherapy.

No scars after new surgery removes brain tumours through the nose

Sun, 02 Oct 2011 11:33:59 -0400

But pioneering brain surgeons at Sheffield’s Hallamshire Hospital have adopted a US-developed technique to reach deep-set tumours using an endoscope that is fed through the nose.

Genome-wide Association Study of Pituitary Tumors

Sun, 02 Oct 2011 11:15:15 -0400

Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.

Help Cushing's Help at No Cost to You

Sat, 01 Oct 2011 11:02:22 -0400

Help Cushing's Help at No Cost to You with iGive.com The iGive.com earnings through May 31, 2011 (quarterly) were $27.81.

'I couldn't walk a few steps without falling'

Tue, 27 Sep 2011 10:06:32 -0400

In 2002 Irene was diagnosed with Cushings Syndrome, following an MRI scan. It emerged that a tumour on her pituitary gland was causing an excess production of cortisol, the stress-relieving hormone.

Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis

Tue, 27 Sep 2011 10:17:39 -0400

A systematic literature search was conducted using Medline, Embase, Web of Science and the Cochran Library for studies reporting data on recurrence of pituitary adenoma after surgery, in nonfunctioning adenoma (NF), prolactinoma (PRL) acromegaly (ACRO) and Cushing’s disease (CUSH). Of 557 initially retrieved potential relevant studies 143 were selected.

Local author fights back from stroke

Sun, 25 Sep 2011 19:13:21 -0400

4 years of medical testing later her doctor discovered that she had Cushing's Syndrome (Pituitary)

New Review on Pathologyatlas

Sun, 25 Sep 2011 18:34:26 -0400

Review:

I like this site a lot. It helped get me diagnosed with Cushing's and told me what to expect after surgery.

I think it would be helpful for anyone who thinks they might have Cushing's or if one of their family members is dealing with it.

Real reviews of Cushings-Help

Thu, 22 Sep 2011 09:20:21 -0400

Average Overall Rating
Cushings (cushings-help.com) 5 out of 5 based on 27 user reviews.

Latest: SusanM: Amazing Website
After twenty-seven years and having seen 14 endocrinologists, I found this website. I travelled to see one of the doctors on the helpful doctors list and diagnosed with Cushings Disease. The MRI the next day confirmed the tumor on the pituitary gland.

I learned much from this site. I learned that it takes patience and persistence with this disease. I also learned that a patient must be put through a full testing protocol to rule in or rule out Cushings. I also learned that there is much to be learned by the medical profession about this disease that is not widely known.

MaryO, you are amazing. Your website is also amazing. Thank You.

An Award for the Cushie.info Blog

Wed, 21 Sep 2011 18:52:15 -0400

The Registered Nurses site awarded us as a Top Cushings Syndrome Blog

Erin Kelley treated for Cushing's Syndrome

Sun, 18 Sep 2011 12:35:19 -0400

Erin Kelley was diagnosed with Cushing's Syndrome, which is a pituitary gland tumor. She was treated with a simple endonasal, skull-base surgery by specialists here at Barnes-Jewish Hospital.

Finding a cure for Cushing's disease

Sun, 18 Sep 2011 10:51:17 -0400

Cushing's disease is a rare but sometimes fatal hormonal disorder that has few treatment options. Researchers in Los Angeles are using a very unusual little fish to try to find help for people who suffer with the disease.

Selective inferior petrosal sinus sampling without venous outflow diversion in the detection of a pituitary adenoma in Cushing’s syndrome

Thu, 18 Aug 2011 09:54:37 -0400

BIPSS remains the gold standard in the detection of a microadenoma in Cushing's Syndrome.

Investigational Cushing’s Drug Eases Symptoms, Ups Hyperglycemia

Sat, 13 Aug 2011 16:09:02 -0400

In the largest clinical trial ever conducted in Cushing’s disease, pasireotide, an investigational somatostatin analogue, was shown to result in a rapid and sustained reduction in urinary free cortisol in the majority of patients, and significantly improved signs and symptoms of the disease.

Endocrine Outcome in Long-Term Survivors of Childhood Brain Tumors

Sat, 13 Aug 2011 16:07:52 -0400

Hypocortisolism was diagnosed in 9 patients, short stature in 20 patients and obesity in 8 male patients.

MaryO was Interviewed in The Coffee Klatch Tonight

cushingshelp@gmail.com — Mon, 15 Aug 2011 18:38:47 -0400

Mary O'Connor, President, Cushings Help Organization joins us to discuss this endocrine disorder that affects both children and adults.

Archives are available.

Cushing's Help and Support - 11 years old and growing strong!

Fri, 22 Jul 2011 13:10:05 -0400

This website (http://www.cushings-help.com ) first went "live" July 21, 2000 and the message boards September 30, 2000. Hopefully, with this site, I’ve made some helpful differences in someone else's life. Who could have known how this site – now sites – could have grown and grown. It started as a one-page bit of information about Cushing’s In people, not dogs, horses, ferrets…

Combined Pituitary Function Test

Sun, 10 Jul 2011 21:47:09 -0400

Combined Pituitary Function Test

Unusually overweight woman with Cushing's Syndrome to get treatment

Sun, 10 Jul 2011 09:33:50 -0400

In Sambrano's case, a tumor in her pituitary gland causes an imbalance in her hormone levels, which results in her continuous growth even though she does not overeat.

Google+ One button added to all pages of cushie.info

Sat, 09 Jul 2011 10:00:57 -0400

Google+ One button added to all pages of cushie.info and some pages of cushings-help.com

Pituitary Tumor Treatments

Thu, 07 Jul 2011 07:11:55 -0400

Most pituitary surgeries don’t involve cutting into the skull. Surgeons access the gland through the sphenoid sinus, an air-filled space behind the nose, in a procedure known as transsphenoidal surgery. An incision is made either under the patient’s lip or inside the nose. A variation of the surgery using endoscopic assistance is even less invasive.

Pituitary Anatomy

Fri, 01 Jul 2011 12:45:14 -0400

Video: Pituitary Anatomy

Glucocorticoid- and Androgen-Secreting Black Adrenocortical Adenomas: Unique Cause of Corticotropin-Independent Cushing Syndrome

Wed, 29 Jun 2011 15:09:39 -0400

Objective: To describe the unique association of corticotropin-independent Cushing syndrome caused by cortisol- and androgen-secreting black adrenal cortical adenomas with myelolipomatous change.

Paternal deprivation prior to adolescence and vulnerability to pituitary adenomas

Tue, 28 Jun 2011 11:02:40 -0400

Paternal deprivation before adolescence may be a risk factor for prolactinoma and acromegaly but not for non-secreting pituitary adenomas or Cushing’s disease.

Brain Atrophy and Cognitive Deficits in Cushing's Disease: Reversibility of Cerebral Atrophy in Cushing's Disease

Sat, 25 Jun 2011 11:57:21 -0400

Cerebral atrophy has been shown to be reversible in patients with Cushing's disease. Following resection of adrenocorticotropin hormone-secreting pituitary adenomas, hippocampal formation volume has been shown to increase by as much as 10%.

UQ Biomedical Scientists Achieve Breakthrough In Growth Hormone Research, Australia

Sat, 25 Jun 2011 11:57:28 -0400

Researchers in the School of Biomedical Sciences at The University of Queensland (UQ) have made a ground-breaking discovery in the study of growth hormone...

This unique innovative method will be used in a number of projects to show the critical involvement of growth hormone in the development of obesity; the impact of stress on the secretion of growth hormone; the impact of growth hormone on ageing; and the role of growth hormone in disease progression in, for example, Motor Neuron Disease.

New Video: Cushing's Syndrome vs. Addison's Disease

Sat, 25 Jun 2011 11:36:07 -0400

New Video: Cushing's Syndrome vs. Addison's Disease

Pituitary Surgery Video

Thu, 23 Jun 2011 16:46:59 -0400

Pituitary Surgery Video

Check-Up: Cushing's Syndrome

Wed, 22 Jun 2011 01:51:04 -0400

I’ve been diagnosed with Cushing’s syndrome which my doctor says is the result of many years of steroid use for rheumatoid arthritis.

A New FAQ (Frequently Asked Questions) is being added. 109 questions answered so far.

cushingshelp@gmail.com — Sat, 18 Jun 2011 20:45:03 -0400

Welcome to the new Cushing's Help and Support FAQ (frequently asked questions) page. This new area will be a compilation of our visitors most frequent questions. Questions and answers are still being added.

Please select either a category on the left, or type in a keyword to search the database of questions and answers. Please note that there are several questions waiting to be answered at this time. Your question will be answered as soon as possible. If your question is very urgent, you might want to check the message boards to see if your question has been answered, or add it yourself.

IMPORTANT: The information and material posted on this Web site is intended as general reference information only. Specific facts and circumstances may alter the concepts and applications of materials and information described herein. The information provided is not a substitute for professional advice and should not be relied upon in the absence of such professional advice specific to whatever facts and circumstances are presented in any given situation.

Rest In Peace, Sarah! New information added about a new park bench in Sarah's memory

Sat, 18 Jun 2011 14:02:53 -0400

Sarah recently had surgery to remove a tumor from her pituitary gland in the hopes of treating her Cushing's Disease. She died on June 13, 2011 after a brief illness at the age of 28.

More information will be provided when it becomes available.

Dr. Theodore Friedman Interviews

Sat, 18 Jun 2011 13:21:28 -0400

Dr. Friedman's career reflects his ongoing quest to better understand and treat endocrine problems. With both medical and research doctoral degrees, he has conducted studies and cared for patients at some of the country's most prestigious institutions, including the University of Michigan, the National Institutes of Health, Cedars-Sinai Medical Center, and UCLA's Charles Drew University of Medicine and Science.

Familial Pituitary Tumor Syndromes

Fri, 17 Jun 2011 14:13:04 -0400

Familial pituitary tumors are rare and comprise approximately 5 % of all pituitary adenomas. Currently, there are four recognized inherited syndromes that involve pituitary tumorigenesis - multiple endocrine neoplasia type 1 (MEN 1) and type 4 (MEN 4), Carney complex and familial isolated pituitary adenomas (FIPA).

Sad, But True2...A Day In the ER

Fri, 17 Jun 2011 05:55:10 -0400

An xtranormal video by by smmmcclain@ucdavis.edu

Dr. Theodore C. Friedman has answered many of our questions

Fri, 17 Jun 2011 22:29:44 -0400

Theodore C. Friedman, M.D., Ph.D. has opened a private practice, specializing in treating patients with adrenal, pituitary, thyroid and fatigue disorders. Dr. Friedman has privileges at Cedars-Sinai Medical Center and Martin Luther King Medical Center. His practice includes detecting and treating hormone imbalances, including hormone replacement therapy. Dr. Friedman is also an expert in diagnosing and treating pituitary disorders, including Cushings disease and syndrome.

More about Zebrafish

Fri, 17 Jun 2011 05:07:33 -0400

A common, tiny tropical fish plays a key role in a new model for Cushing disease, giving researchers a powerful tool to conduct extensive searches for effective treatments for this serious hormonal disorder, testing up to 300 drugs weekly.

Cushie Bookstore

Fri, 17 Jun 2011 04:40:11 -0400

I found these books from amazon.com useful and interesting.

Cushing's and Cancer - the Reality of it all

Thu, 16 Jun 2011 12:06:11 -0400

This post is by Judy, a long-time message board member who is in the middle of Cushing’s patients. Both children and her ex-husband have dealt with Cushing’s. Judy is a Cushie-Blogger.

Cushing's Disease Treatment

Wed, 15 Jun 2011 18:36:20 -0400

A 19-year-old woman was referred to Dr. Adriana Ioachimescu for evaluation following an abnormal 1-mg dexamethasone suppression test. She started to experience weight gain, hirsutism and oligomenorrhea at age 16. At that time, she was diagnosed with type 2 diabetes, which was not controlled, despite oral medications and 200 units of insulin daily. A few months before her initial visit to the Emory Pituitary Center, the patient experienced a hip fracture and required surgery. On examination, it was discovered that she had typical Cushing’s stigmata, severe proximal myopathy and depression. She was unable to walk without assistance.

LindaP's Cushing's Tips

Tue, 14 Jun 2011 21:37:01 -0400

Linda writes: "I have learned so much on this Cushing's journey, much of it from all of you and this site. I wanted to share those learnings, in the event that it helps anyone else."

Pituitary Surgery Observations

Tue, 14 Jun 2011 10:03:01 -0400

It is strange to be writing to you from the other side of surgery (well, at least this time somewhat coherently, as my prior post-op posts have been, let's say, lubricated nicely by some very nice pain pills). It seems not too long ago, I was writing my introduction post back in August, then posting questions about testing, months of which are now thankfully over.

Packing Suggestions for Surgery

Tue, 14 Jun 2011 09:19:06 -0400

New Cushings group on empowHER / New member joined

Fri, 10 Jun 2011 20:37:51 -0400

Whenever there's a new service, or site, I like to try it out to reach as many people with Cushing's as possible. I know that all Cushies aren't on Facebook, or Twitter or even on the Cushing's Help message boards. So, I'm giving this a whirl :)

Cushing's Disease / Kidney cancer

Wed, 08 Jun 2011 17:06:35 -0400

MaryO's Story on EmpowHER - Cushing's Disease / Kidney cancer. Comments welcome.

Drugs that might interfere with Cushing's testing.

Tue, 07 Jun 2011 09:19:26 -0400

Drugs that might interfere with Cushing's testing.

NIH Adrenal Clinical Trials Updated 6/6/2011

Mon, 06 Jun 2011 20:39:20 -0400

adrenal, adrenalectomy, clinical trial, Conn Syndrome, Cushing's, NIH, pheochromocytoma, pituitary, tumor

Diet and Exercise with Cushing's

Mon, 06 Jun 2011 13:04:36 -0400

Investigational drug improves symptoms of Cushing’s disease

Mon, 06 Jun 2011 12:12:37 -0400

Phase 3 data from the PASPORT-CUSHINGS trial show significantly reduced cortisol levels and improved quality of life in patients with Cushing’s disease who were assigned to pasireotide.

An endoscopic modification of the simultaneous ‘above and below’ approach to large pituitary adenomas

Mon, 06 Jun 2011 11:44:43 -0400

This modified approach has the advantages of requiring only one operating microscope, and permitting freer maneuvers and easier orientation for both surgical teams. We present two patients successfully treated with this approach. Complete tumor removal was achieved and both patients achieved satisfactory functional recovery.

Pituitary autoimmunity is associated with hypopituitarism in patients with primary empty sella

Sun, 05 Jun 2011 20:29:44 -0400

Objective: some evidences suggest that late stage autoimmune hypophysitis (AH) may result in empty sella (ES). Aim of the study was to assess the prevalence of serum pituitary antibodies (PitAbs) and their correlation with pituitary function in patients with ES.

ENDO: New Agent Targets Cause of Cushing's Disease

Sun, 05 Jun 2011 20:18:08 -0400

Currently, there are no medical therapies specifically indicated for Cushing's disease. Surgery is the main therapeutic option, followed by radiation, and a handful of medications are used off-label.

Washington: Neurological Surgery Clinical Services Pituitary Disorders

Sun, 05 Jun 2011 20:00:53 -0400

Our team comprises specialists whose multidisciplinary experience guides the diagnosis and treatment of hypothalamic-pituitary disorders and tumors. Patients benefits from the collective wisdom of our multidisciplinary team. Physicians meet to review each case, discuss standard care, problem-solve and generate a consensus recommendation for next steps.

NIH Pituitary Clinical Trials Updated 6/5/2011

Sun, 05 Jun 2011 19:47:32 -0400

adrenal, adrenalectomy, clinical trial, Conn Syndrome, Cushing's, NIH, pheochromocytoma, pituitary, tumor

Cushing's Testing Pathway

Sat, 04 Jun 2011 15:36:43 -0400

Cushing's Testing Pathway

PDF Files (last updated June 4, 2011)

Sat, 04 Jun 2011 15:30:24 -0400

PDF Files (last updated June 4, 2011)

Overlapping conditions and clinical features of Cushing’s syndrome

Sat, 04 Jun 2011 15:07:12 -0400

Overlapping conditions and clinical features of Cushing’s syndrome

Current Clinical Practice Guidelines

Sat, 04 Jun 2011 02:44:35 -0400

The Diagnosis of Cushing's Syndrome. The Endocrine Society's published clinical practice guidelines. Download each guideline, free-of-charge

NIH Cushing's Syndrome Survey

Sat, 04 Jun 2011 02:44:27 -0400

Patients with Cushing's syndrome report decreased quality of life before and after surgical treatment. We are investigators at the U.S. National Institutes of Health who care for patients with Cushing's syndrome. We want to learn more about the patients' experience during the post-surgical recovery phase with particular reference to quality of life. We are inviting patients like you who have had surgical treatment to complete the survey. Your responses will be gathered anonymously and will be treated confidentially; we hope to use them in a publication so that other physicians can learn about these issues.

NIH Cushing's Clinical Trials Updated 6/4/2011

Sat, 04 Jun 2011 02:06:52 -0400

adrenal, adrenalectomy, clinical trial, Conn Syndrome, Cushing's, NIH, pheochromocytoma, pituitary, tumor

Stress Science: Neuroendocrinology

Thu, 02 Jun 2011 13:50:57 -0400

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing's Syndrome: Addison's Disease) and the adverse impact of stress on human physical and mental health.

Surgical Removal Pituitary Tumor Macroadenoma

Thu, 02 Jun 2011 10:16:36 -0400

Clips from removal surgery of pituitary tumor macroadenoma. Courtesy of Dr. Farhad Limonadi, MD. For more information on on medical cases, surgery and video please visit www.microneurosurgery.org

Care for Pituitary Tumors at University of Colorado Hospital

Thu, 02 Jun 2011 08:01:46 -0400

With just the right balance of patient care, research and education, University of Colorado Hospital provides the highest quality treatment for pituitary tumors in the nation.

Immunohistochemical Expression of Neuroendocrine Secretory Protein-55 (NESP-55) in Pituitary Adenomas

Thu, 02 Jun 2011 07:49:24 -0400

The highest levels of NESP-55 expression, at least in animals, appear to be in the adrenal medulla and the pituitary gland. However, very little is known about the status of NESP-55 expression in pituitary adenomas.

(Addison's Disease) Consider Celiac Disease in Autoimmune Disorder Patients

Thu, 02 Jun 2011 07:45:09 -0400

The strongest associations between celiac disease and systemic autoimmune disease are with adult idiopathic diabetes mellitus, autoimmune thyroid disease, Addison’s disease, and polyendocrinopathies, she added.

Have You Been Helped by Health IT?

Thu, 02 Jun 2011 01:40:37 -0400

On June 20th we are hosting NHIN 304 – HIE Success Stories from the Patient Perspective. Our goal for that class is to get some stories from/focusing on patients whose health was improved or whose care was made more effective as a result of health information technology and exchange. ...

Cushing’s Syndrome Can Cause Stretch Marks

Mon, 30 May 2011 21:33:33 -0400

Cushing’s Syndrome is a disease that causes stretch marks to appear. Two other diseases that act in the same way as Cushing’s Sydrome are Marfan syndrome and Ehlers-Danlos Syndrome

Author talks about Cushing's in Podcast

Sat, 28 May 2011 16:43:44 -0400

Hello all! As some of you know I have written and published a book. I'll be interviewed tomorrow (May 25, 2011) and I asked the interviewer if, along with questions about my book, she would ask one or two questions about Cushing's. TRYING to get the word out! I'm also doing a blog tour and most of the hosts have been kind enough to put my bio up on their sites which includes information about cushing's and this site.

Updated with link to podcast.

Cushing's Help Family of Sites

cushingshelp@gmail.com — Fri, 27 May 2011 10:27:57 -0400

Also in the Cushings-Help family of websites...

The Endocrine System - in poster form

Fri, 27 May 2011 10:27:55 -0400

Note that several areas have scroll bars for more info.

New! Open Cushing's Help Group on LinkedIn

Thu, 26 May 2011 03:25:34 -0400

New! Open Cushing's Help Group on LinkedIn

NIH: 25 Years of Improving Lives Through Discovery: 1986 – 2011

Wed, 25 May 2011 04:50:33 -0400

On Monday, June 13, 2011, the NIAMS will host its 25th Anniversary Scientific Symposium: Improving Lives Through Discovery. The Symposium will feature scientific advances made possible with NIAMS support, highlight how these advances have improved patients' lives, and address the future directions for NIAMS research.

NIH: Children's Inn At NIH

Wed, 25 May 2011 03:56:22 -0400

The Children's Inn at NIH, a non-profit lodging facility, aims to provide "a place like home" for sick children undergoing treatment at NIH, along with their families.

Growth Hormone improves stroke recovery

Wed, 25 May 2011 03:39:26 -0400

Researchers at the Sahlgrenska Academy in Gothenburg assessed the progress of 407 patients aged between 18 and 70; all had all had a stroke and were then followed for two years afterwards. Measuring levels of a specific hormone – insulin-like growth factor 1 (IGF-1) - the researchers found that patients who recovered most successfully also had higher levels of the hormone. This remained true for up to two years after the stroke.

Addison's Disease knol

cushingshelp@gmail.com — Tue, 24 May 2011 11:25:30 -0400

All about Addison's Disease, by MaryO

Prevalence and Incidence of Diabetes Mellitus in Adult Patients on Growth Hormone Replacement for Growth Hormone Deficiency

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:03 -0400

GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM).

Cushing's Awareness Day passes but disease lingers for reader

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:10 -0400

The most common symptoms include a rounded face and upper body (abdomen, upper back, neck and between the shoulders ("buffalo hump"), obesity and relatively slender arms and legs.

Other symptoms can include acne, slow-healing cuts, bites or infection, bone loss, muscle weakness, fatigue, cognitive difficulties, high blood pressure, high blood glucose levels, headaches, thin skin with easy bruising, purple/red stretch marks, depression and/or anxiety, abnormal menstruation and excess body and facial hair in women, and erectile dysfunction and a decrease in libido and fertility in men. Children typically present with obesity and slowed growth.

Updated: Cushing's Group on Posterous

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:25 -0400

Yet another way for Cushies to communicate. Whenever there's a new service, or site, I like to try it out to reach as many people with Cushing's as possible. I know that all Cushies aren't on Facebook, or Twitter or even on the Cushing's Help message boards. So, I'm giving this a whirl :)

My battle with Cushing's disease

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:30 -0400

I have lost 65 pounds since my surgery and I am feeling better. I am still on a lot of medicines but I am almost back to the way I was before. My old clothes fit me again and I feel more confident. However, every time I think about what I "got through" I think about and glance down at the battle scars that Cushing's left me that will never go away, for they will only fade in time except for when the blood pulses through my veins.

Overactive adrenal glands (Cushing's syndrome)

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:40 -0400

The symptoms (and treatment) of overactive adrenal glands depends on which hormone is being overproduced.

Growth Hormone and the Hypothalamic-Pituitary-Somatotrophic Axis

cushingshelp@gmail.com — Tue, 24 May 2011 11:26:45 -0400

Growth hormone (GH) or somatotropin is another stress-sensitive neuroendocrine system. GH is synthesized by the anterior pituitary, and although it can be used as an endpoint in itself for neuroendocrine research in psychiatry, its predominant use is as a marker of the integrity of the noradrenergic system following challenge

Archived Articles

cushingshelp@gmail.com — Tue, 24 May 2011 11:31:41 -0400

Past articles that have been archived. For logged-in members only

Cushings Syndrome Secondary to a Thymic Carcinoid Tumor Due to Multiple Endocrine Neoplasia Type 1

cushingshelp@gmail.com — Tue, 24 May 2011 11:32:46 -0400

Objective: To present an Iranian patient who had a non-classic form of MEN1 and presented with ectopic Cushing's syndrome (CS) secondary to an ACTH-producing thymic neuroendocrine tumor (NET), recurrent renal stones and a giant cell granuloma of the jaw, due to primary hyperparathyroidism (PHPT), without involvement of the pituitary or pancreas.

Adrenal venous sampling is crucial before an adrenalectomy whatever the adrenal-nodule size on computed tomography

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:07 -0400

To assess the additional value of adrenal venous sampling (AVS) to diagnose primary aldosteronism sub-types in patients who have a unilateral nodule detected by computed tomography (CT scan) and who should undergo an adrenalectomy.

(Cushing's) Belinostat abstracts at ASCO 2011

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:13 -0400

Three out of six pts. with TC with neuroendocrine features had Cushing's syndrome.

Salivary Cortisol updated

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:18 -0400

Added patient info that was also added to the CushieWiki

Hair cortisol content in patients with adrenal insufficiency on hydrocortisone replacement therapy

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:27 -0400

Hair cortisol content correlates with hydrocortisone (HC) dose in patients with AI. Our results suggest that some AI patients may be over-treated and hence may be at risk for the adverse effects of cortisol. Measurement of HC in hair may become a useful monitoring tool for long-term cortisol exposure in patients treated with glucocorticoids.

Cushing's Syndrome: All Variants, Detection, and Treatment.

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:32 -0400

Diagnosis of Cushing's syndrome involves a step-wise approach and establishing the cause can be challenging. Several pathogenic mechanisms have been proposed for glucocorticoid-induced hypertension, including a functional mineralocorticoid excess state, upregulation of the renin angiotensin system, and deleterious effects of cortisol on the vasculature. Surgical excision of the cause of excess glucocorticoids remains the optimal treatment. Antiglucocorticoid and antihypertensive agents and steroidogenesis inhibitors can be used as adjunctive treatment modalities in preparation for surgery and in cases where surgery is contraindicated or has not led to cure.

Specific Electrocardiographic Features Associated with Cushing's Disease

cushingshelp@gmail.com — Tue, 24 May 2011 11:33:38 -0400

Hypercortisolaemia is associated with an increased risk of cardiovascular disease (CVD), either through a direct action on the myocardium or by increased traditional cardiovascular risk factors. The aim of this study was to investigate whether the alterations in the ECG in Cushing's disease (CD) are predictable from risk factor analysis alone.

Helpful Hints for Dealing With Cushing's

Tue, 17 May 2011 11:58:20 -0400

Helpful hints for dealing with Cushing's provided by message board members and others.

Teaching Hospitals N to Z

Mon, 16 May 2011 19:37:20 -0400

Teaching Hospitals N to Z

Teaching Hospitals A to M

Mon, 16 May 2011 19:32:46 -0400

Teaching Hospitals A to M

Please Help These Others

Sat, 12 Nov 2011 07:22:57 -0500

As more and more people ask questions and seem lost about Cushing's elsewhere online, their info will be posted here so that board members can respond to them.

A new opportunity added November 12, 2011

Pituitary Hormones and Mental Health

Sat, 07 May 2011 15:14:33 -0400

Pituitary and other hormonal disorders encompass a wide range of symptoms that may appear months or years prior to proper medical diagnosis. Pituitary patients are often the first to recognize that something may be wrong when they find their sexual and/or mental health deteriorating. Symptoms commonly thought of as purely psychological in nature, but common in pituitary disorders, include major depression, suicide, anxiety, weight gain/loss, sexual dysfunction, anger and rage, cognitive disturbances, and more. Other symptoms can have a mental health component. For example, the effects of infertility or loss of libido can impact a couple’s relationship and stability. Lethargy, apathy, and mental slowness all wreak havoc with the ability to function fully in work, family and social environments. Menstrual irregularities and pain can cause losses in work or school productivity. Amenorrhea (absence of menses), especially when accompanied with weight loss, can be mistakenly diagnosed as anorexia nervosa.

Pituitary Hormones

Sat, 07 May 2011 14:55:56 -0400

Diseases and symptoms involving the pituitary gland are varied. Some diseases are related to an overproduction of a specific hormone, or too little to no production. A growth in the pituitary gland could put pressure on the optic nerve or the carotid artery. Surgery involving the pituitary gland is done using minimally invasive, microscopic surgery. The surgeon can go through the sphenoid sinus and there are no visible scars.

The difference between Cushing’s disease and other forms of Cushing’s syndrome

Thu, 05 May 2011 16:01:31 -0400

Cushing’s syndrome is the term used to describe a group of symptoms that occur when a persons’ cortisol levels are too high (known as hypercortisolism) for too long. The majority of people have Cushing’s syndrome because they are regularly taking certain medicine(s) that continually add too much cortisol to the body. Doctors call this an “exogenous” (outside the body) cause of Cushing’s syndrome. Other people have Cushing’s syndrome because something is causing the adrenal gland(s) to overproduce cortisol. Doctors call this an “endogenous” (inside the body) cause of Cushing’s syndrome.

What is the best course of treatment for Cushing's syndrome?

Wed, 04 May 2011 13:47:06 -0400

In some cases, the most difficult part of treating Cushing's syndrome is making the right diagnosis and figuring out what is causing the excessive hormone production. The can be difficult because tumors of both the adrenal glands and pituitary gland are common, and sometimes they exist in a person with Cushing's syndrome without being the cause.

Hormones play a role in all health problems

Wed, 04 May 2011 14:08:58 -0400

Such tests help to diagnose and monitor progress for conditions such as diabetes, Cushing's syndrome, hyperthyroidism (eg Graves disease), hypothyroidism, polycystic ovarian syndrome, glandular tumors (cancer), etc...

Sad, But True...It's Literally Impossible To Have Cushings

Wed, 04 May 2011 13:26:00 -0400

Endocrinologists sometimes have a hard time diagnosing cushing's disease. Here is a scene between one concerned patient and her endocrinologists.

Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor

Tue, 03 May 2011 17:18:15 -0400

Cushing disease caused by adrenocorticotropin (ACTH)-secreting pituitary adenomas leads to hypercortisolemia predisposing to diabetes, hypertension, osteoporosis, central obesity, cardiovascular morbidity, and increased mortality. There is no effective pituitary targeted pharmacotherapy for Cushing disease.

The challenges of diagnosing Cushing’s syndrome

Tue, 03 May 2011 16:46:04 -0400

Being correctly diagnosed with Cushing’s syndrome is the first step toward regaining control of your health because an accurate diagnosis helps your doctor determine the best course of action. Cushing’s syndrome may be challenging to diagnose because of several factors...

New Cushing's Syndrome Interview

Tue, 03 May 2011 16:26:47 -0400

A rare, life-altering disease brought a New Hampshire woman to The Ohio State University Medical Center. Her story is stunning and NBC4 takes you inside the rare disease and her cure.

Spinning Out of Control

Sun, 01 May 2011 12:14:55 -0400

Dr. Hamrahian recalls first meeting Ms. Leslie, who showed him photos of her thin and vibrant self from just a year before. “You couldn’t recognize the same person,” he says. “She was really in need of help.” Cushing’s syndrome can be tricky to diagnose because weight gain and anxiety are common. Depression, obesity, diabetes and other conditions can also elevate cortisol levels. However, looking at Ms. Leslie’s whole clinical picture, Dr. Hamrahian diagnosed Cushing’s. Excessive cortisol causes skin atrophy, loss of collagen and insulin resistance, the reasons for Ms. Leslie’s stretch marks, bruising and weight gain.

Congenital adrenal hyperplasia (CAH)

Sun, 01 May 2011 11:51:38 -0400

Congenital adrenal hyperplasia is a genetic disorder affecting 1:10,000 to 1:15,000 newborns worldwide and the most severe form of the disease can lead to a life-threatening condition during the first weeks of life. The disease is caused by enzyme defects in the steroid biosynthesis, the most frequent types being 21- and 11a-hydroxylase deficiency. In both of these the17a-OH-progesterone, a precursor for cortisol, is increased which makes its determination a useful screening method for 95% of all of the CAH cases.

Cushing’s syndrome in pregnancy

Sat, 30 Apr 2011 20:55:02 -0400

A 22-year-old G1P0 was admitted at 26 weeks gestation for preeclampsia, hyperglycaemia and cushingoid features. Elevated 24-h urine free cortisol (UFC) and suppressed plasma adrenocorticotrophic hormone (ACTH) suggested ACTH-independent Cushing’s syndrome. Ultrasound showed left adrenal mass...

Radiation Therapy in the Management of Pituitary Adenomas

Thu, 28 Apr 2011 18:19:11 -0400

A literature search through the U.S. National Library of Medicine was used to identify and review clinical experiences of radiation therapy in the management of pituitary adenomas. Emphasis was placed on studies within the last 5–10 yr, with 5 or more years of follow-up data, and of reasonable quality of data. Older studies with larger numbers or particular significance are also highlighted.

Type 1 Diabetes, Celiac or Addison’s?

Thu, 28 Apr 2011 09:55:29 -0400

It has recently been reported that fifteen to thirty percent of people with Type 1 diabetes have also been diagnosed, and about 4 to 9 percent have been diagnosed with celiac disease. Addison’s disease is at the bottom of the list with less than one percent being diagnosed. Children who have been confirmed to have diabetes should be tested yearly for an autoimmune thyroid disease, and for celiac disease if other symptoms become apparent. There is no real screening schedule for Addison’s disease.

Adrenal Medulla

Thu, 28 Apr 2011 09:49:13 -0400

The endocrine glands that are present on the kidneys are called as adrenal glands. These suprarenal glands or adrenal glands produce hormones when the body is under stress. They also affect the kidney function by secreting a hormone aldosterone. When we have a look at the adrenal gland anatomy, we find these glands are surrounded by adipose capsule and renal fascia. There are two distinct parts that make up the adrenal glands. These include the adrenal cortex and the adrenal medulla. Both these parts produce hormones. The adrenal cortex produces cortisol, aldosterone and androgen hormones. In the following paragraphs, we shall concentrate more on adrenal medulla hormones and their functions.

Noninvasive brain surgery

Wed, 27 Apr 2011 11:07:42 -0400

The Gamma Knife is a revolutionary breakthrough in brain surgery. It uses radiation produced by 201 beams of cobalt-60 to treat brain tumors, AVMs, and trigeminal neuralgia, among brain diseases. The radiation is so precise that normal brain tissue is unaffected.

Cushing's Diagnosis ~ Think Like a Doctor: A Litany of Symptoms Solved!

Wed, 27 Apr 2011 03:57:50 -0400

The wide range of complaints that characterize Cushing’s syndrome was first described by Dr. Harvey Cushing in 1932. In this disease, the adrenal glands churn out too much cortisol, an essential hormone involved in our body’s response to stress. Cortisol helps maintain blood pressure, reduces the immune system’s inflammatory response and increases blood sugar levels — all vital processes for helping our bodies cope with biological and environmental stress.

But long-term exposure to high levels of cortisol can cause osteoporosis, diabetes, high blood pressure, muscle weakness, memory loss and psychiatric disease. It causes the skin to thin and weaken, making it susceptible to bruises that are often dark and dramatic looking. The lesions on this patient’s arms and legs were signs of this.

Gastric inhibitory polypeptide-dependent cortisol hypersecretion--a new cause of Cushing's syndrome.

Wed, 27 Apr 2011 03:58:02 -0400

Nodular adrenal hyperplasia and Cushing's syndrome may be food-dependent as a result of abnormal responsiveness of adrenal cells to physiologic secretion of GIP. "Illicit" (ectopic) expression of GIP receptors on adrenal cells presumably underlies this disorder.

Cushing's Final Output

Wed, 27 Apr 2011 03:22:48 -0400

MNEMONICC
-
C
entral obesity,
C
ervical fat pads,
C
ollagen fibreweakness,
C
omedones (acne)
U
- Urinary free cortisol and glucose increase
S
-Striae, Suppressed immunity
H
- Hypercortisolism, Hypertension, Hyperglycaemia, Hirsutism
I
- Iatrogenic (Increased administration of corticosteroids)
N
- Noniatrogenic (Neoplasms)
G
- Glucose intolerance, Growth retardation

Doctors Perform Brain Surgery...Through The Nose

Tue, 26 Apr 2011 11:29:37 -0400

While this type of surgery can prove to be remarkably effective, it is still fairly rare. Prevedello says only a few medical centers around the world offer the two-surgeon, endoscopic endonasal approach. In fact, several doctors from Europe spent several weeks in Columbus training in this technique with surgeons at Ohio State’s James Cancer Hospital.

Calories & Cushing's Disease

Tue, 26 Apr 2011 11:19:31 -0400

While there's usually no way to avoid weight gain with Cushing's disease, you can often minimize it by limiting your caloric intake. The number of calories, however, varies greatly from person to person. This is at least partly why the Warren Grant Magnuson Clinical Center at the National Institutes of Health recommends talking to a dietitian to establish the appropriate caloric intake for you. Not only is your caloric need affected by the disease, but it's also based on your height, weight, gender, age and level of physical activity.

Endocrine Society Releases Guidelines on Pituitary Incidentalomas

Tue, 26 Apr 2011 11:09:41 -0400

The guidelines include recommendations on the initial evaluation of patients, follow-up testing of patients who do not meet criteria for surgical removal of the lesion, and medical therapy. For example, after an incidentaloma is identified, a patient should undergo a complete history and physical examination “that includes evaluations for evidence of hypopituitarism and a hormone secretion syndrome,” as well as biochemical evaluations, if there is evidence for either of these conditions, the guidelines state.

Diagnosing Cushing's

Thu, 21 Apr 2011 21:30:17 -0400

Random postoperative day 3 cortisol as a predictor of hypothalamic-pituitary-adrenal axis integrity after transsphenoidal surgery

Fri, 15 Apr 2011 21:16:47 -0400

In the appropriate clinical context, a POD3 cortisol ≥10μg/dl accurately predicts the integrity of the HPA axis. The final decision regarding corticosteroid replacement should be individualized, taking into consideration the POD3 cortisol level, the clinical context in which the measurement was obtained, and any evidence of concomitant pituitary dysfunction in the perioperative period.

Obesity is a Predictor of Morbidity in 1,629 Patients Who Underwent Adrenalectomy

Fri, 15 Apr 2011 21:05:43 -0400

There were 1,629 patients in the study: 22% were normal weight, 31% overweight, 22.2% obese, and 24.7% morbidly obese. Compared to normal-weight patients, obese and morbidly obese patients had a 12.5 and 16.7% increase in operation times (129 vs. 145 and 150 min, respectively, p ≤ 0.01) and sustained more wound complications (0.2 vs. 0.4 and 1.2%, p < 0.001), including superficial and deep wound infections (p < 0.001 and p < 0.01, respectively). Morbid obesity independently predicted overall complications (odds ratio [OR] 2.9, 95% confidence interval [CI]: 1.7–5.7), wound complications (OR 6.1, 95% CI: 2.0–18.9), and septic complications (OR 3.1, 95% CI: 1.1–8.8). Obesity independently predicted longer total time in the operating room (p < 0.006). There were no differences in rates of reoperation and length of hospital stay by BMI category.

Treatment Guidelines for Pituitary Incidentalomas Issued

Fri, 15 Apr 2011 20:49:01 -0400

Medical therapy for pituitary incidentalomas has not been systematically studied, the authors note. "In patients with incidentalomas and hyperprolactinemia that may be due to tumoral compression of the hypothalamic-pituitary stalk, symptomatic hyperprolactinemia may be treated with a dopamine agonist," they write. However, they add that incidentalomas other than a prolactinoma are unlikely to shrink, and lesions should still be monitored regardless of changes in prolactin levels.

Pathophysiology Cushing's Syndrome

Fri, 15 Apr 2011 20:43:30 -0400

Pathophysiology Cushing's Syndrome

Updated Cushing's Help and Support Printable Brochure

Thu, 14 Apr 2011 11:10:24 -0400

Updated Cushing's Help and Support Printable Brochure

Print them on special tri-fold brochure paper and that works out well.

I update these after each meeting, when I have new pictures, so if you print them out, check back now and then for the latest copy.

Newest version has a Columbus, OH picture.

Pituitary hyperplasia secondary to acquired hypothyroidism: case report

Sun, 10 Apr 2011 14:36:49 -0400

Conclusion: primary hypothyroidism should be considered in the differential diagnosis of solid mass lesions of the pituitary gland. Examination of thyroid function in patients with sellar and suprasellar masses revealed by MRI may avoid unnecessary operations which can cause irreversible complications.

Clinical Trial: Safety and Efficacy of LCI699 in Cushing's Disease Patients

Sat, 09 Apr 2011 13:32:09 -0400

This exploratory study is a proof of concept study to determine whether LCI699 can safely reduce the level of urinary free cortisol in patients with Cushing's disease...

Clinical Trials for Cushing's Syndrome

Sat, 09 Apr 2011 12:08:33 -0400

Clinical Trials for Cushing's Syndrome

Presentation of Primary Adrenal Insufficiency in Childhood

Sat, 09 Apr 2011 12:09:37 -0400

Primary adrenal insufficiency is usually diagnosed in infancy or adulthood, and cases presenting in childhood have not been systematically reviewed.

Low Incidence of Adrenal Insufficiency after Transsphenoidal Surgery in Patients with Acromegaly: A Long-Term Follow-Up Study

Sat, 09 Apr 2011 12:10:15 -0400

The objective of the study was to assess the prevalence and incidence rates of adrenal insufficiency in consecutive patients during long-term follow-up after successful transsphenoidal surgery for acromegaly.

Pituitary tumor: Optician check-up `helped man discover cause of vision problems

Sat, 09 Apr 2011 11:42:26 -0400

By paying a visit to an optician in Edinburgh, a man was able to rescue his sight thanks to the detection of a major health problem, it has been revealed.

The Edinburgh Evening News has reported on the experience of 62-year-old Blackhall man Scott Anderson, who found out that he had a pituitary brain tumour after an appointment he had with KD Wallace Optometry.

Sphenoid sinus pyocele after transsphenoidal approach for pituitary adenoma

Fri, 08 Apr 2011 11:09:07 -0400

A patient presented to our outpatient clinic 8 months after transsphenoidal surgery for selective removal of a pituitary adenoma because of an acute onset of frontal headache during an airplane travel, fever and pulsating sensation in left eye and ear. MRI revealed a contrast-enhancing lesion in the left inferior portion of the sphenoid sinus.

Expression and Roles of Pannexins in ATP Release in the Pituitary Gland

Fri, 08 Apr 2011 11:00:01 -0400

Pannexins are a newly discovered three-member family of proteins expressed in the brain and peripheral tissues that belong to the superfamily of gap junction proteins. However, in mammals pannexins do not form gap junctions, and their expression and function in the pituitary gland have not been studied

Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy.

Fri, 08 Apr 2011 10:46:45 -0400

Cushing's syndrome is rare in children and adolescents. We analyzed the clinical presentation, diagnostic evaluation, and treatment of 59 patients with Cushing's syndrome between the ages of 4 and 20 years who were admitted to the National Institutes of Health during the period from 1982 to 1992. The cause of hypercortisolism was identified by low- and high-dose dexamethasone suppression tests, the ovine corticotropin-releasing hormone (CRH) stimulation test, imaging studies, and bilateral sampling of the inferior petrosal sinuses combined with administration of CRH.

Cushing's Awareness Day!

Fri, 08 Apr 2011 08:40:10 -0400

April 8th is Cushing's Awareness Day. Please wear your Cushing's ribbons, t-shirts, awareness bracelets or Cushing's colors (blue and yellow) and hand out Robin's wonderful Awareness Cards to get a discussion going with anyone who will listen. And don't just raise awareness on April 8. Any day is a good day to raise awareness.

Famed Neurosurgeons Century-Old Notes Reveal Modern Style Admission of Medical Error

Mon, 04 Apr 2011 20:07:59 -0400

Latimer and her colleagues scoured Johns Hopkins' archives to locate operative notes covering 878 of Cushing's patients. The notes, transferred decades ago to microfilm, covered the early years of Cushing's career, from 1896 to 1912, at The Johns Hopkins Hospital. After deciphering the notes -- a monumental task, the authors say, owing to Cushing's poor handwriting, abbreviations, and pages crowded with notes of other physicians, too -- the researchers selected 30 cases in which errors were clearly delineated.

Dr. Harvey Williams Cushing (1869-1939)

Sat, 02 Apr 2011 10:27:42 -0400

In addition to his pioneering work in performing and teaching brain surgery, he was the reigning expert on the pituitary gland since his 1912 publication on the subject; later he discovered the condition of the pituitary now known as "Cushing's disease".

2011 Cushing's Awareness Day at Jimmy Buffett's Margaritaville

Sat, 02 Apr 2011 10:30:01 -0400

Why is Jimmy Buffett's Margaritaville interested in Cushing's? Listen to Melissa's interview. Her sister has had 2 Cushing's pituitary surgeries. There is another family member who was born with Addison's Disease.

Melissa is the Parrot Head Club Liaison for Jimmy Buffett's Margaritaville Key West. In this capacity, she has advanced Cushing's Awareness by adding links and info to the Margaritaville website because they like to highlight worthy and wonderful organizations.

(Cushing's patient) Zumba becomes more than a dance, it's a way of coping

Thu, 31 Mar 2011 15:40:39 -0400

Zumba also helped Padilla heal from Cushing's disease after she was diagnosed in June 2009. Cushing's disease is a disorder resulting from prolonged exposure of the body's tissues to high levels of the hormone cortisol, which is released from the pituitary gland.

"We need cortisol, but when it is in excess, it becomes dangerous because it eats away at our muscles and bones," said Padilla. "It also causes acne, dry skin, thin arms and a large upper body, fatigue, unexplained bruises and an occasional moon face."

(Cushing's patient) Durham woman plans prom for ill, disabled youth

Tue, 29 Mar 2011 10:59:24 -0400

A Durham woman waiting on a double lung transplant is trying to help inspire young adults and teens in a similar situation...

In high school, Sjostedt-Smith was diagnosed with Cushing's disease, which causes fluid to build up in her brain and lungs. The disease kept her from going to her own prom.

(Clinical Trial) Versartis starts test of growth hormone therapy

Tue, 29 Mar 2011 10:49:36 -0400

Versartis Inc. started a Phase I clinical trial of a treatment for growth hormone deficiency (VRS-317).

Pituitary Adenomas

Tue, 29 Mar 2011 10:36:09 -0400

Pituitary adenomas are common benign tumors of the pituitary gland. It is said that up to 10% of people will have a pituitary adenoma (which might never have caused a problem) by the time of their death. Some tumors secrete one or more hormones in excess. Such so-called secretory pituitary adenomas are usually found due to hormonal imbalances that affect bodily functions. They may be relatively small when detected.

People can develop pituitary adenomas at any age. Most pituitary adenomas are in the front part (anterior lobe) of the pituitary gland.

Adult Growth Hormone Deficiency: Unreplaced Sex Steroid Deficiency, Corticotropin Deficiency, and Lower IGF-I Are Associated with Lower Bone Mineral Density in Adults with Growth Hormone Deficiency

Wed, 23 Mar 2011 14:14:19 -0400

A total of 1218 subjects with stringently defined GHD of adult onset (641 women and 577 men) who were GH naïve and had BMD measured in the posterior anterior lumbar spine and femoral neck by dual-energy X-ray absorptiometry.

I Was Diagnosed with a Pituitary Tumor…Now What?

Sun, 20 Mar 2011 11:11:01 -0400

Join Johns Hopkins neurosurgeon and surgical director of the Pituitary Center, Alfredo Quinones-Hinojosa, M.D., for a free online seminar about what people diagnosed with a pituitary brain tumor, their family members and caregivers should know about this condition, the latest treatment options available and what to expect after treatment.

DATE/TIME: April 5, 2011 - 7 p.m. to 8 p.m. (EST)

Effects of Once-Weekly Sustained-Release Growth Hormone: A Double-Blind, Placebo-Controlled Study in Adult Growth Hormone Deficiency

Thu, 17 Mar 2011 10:57:03 -0400

Conclusions: Weekly GH replacement with the sustained-release preparation LB03002 in adults significantly reduced FM over 6 months and was well tolerated.

Spread The Word! Cushing's Pocket Reference

Thu, 17 Mar 2011 10:57:22 -0400

Robin has provided Cushing's Pocket References for us to print out on business cards.

Hand these out whenever you think you might see someone with Cushing's.

(Book) Cushing's Disease

Tue, 15 Mar 2011 18:16:48 -0400

In Cushing’s Disease, leading authorities in the field offer a thorough review of the pathogenesis, diagnostic algorithm and treatment options for this complex disease. Beginning with a fascinating history of Cushing's disease that outlines its historical significance to both endocrinology and neurosurgery, the book goes onto to cover the full range of important issues, including the molecular pathogenesis of Cushing’s, anatomic pathology, the diagnosis of Cushing's syndrome, the differential of pseudo-Cushing's syndromes, hypercortisolemia, surgical removal of the corticotroph adenoma, post-operative management and assessment of remission, radiotherapeutic options, and the exciting developments in medical therapy. In addition, the book also addresses Cushing's disease in the pediatric population, given that its clinical manifestations and impact on growth can be severe; silent corticotroph adenomas as a distinct clinical entity; diagnosis and management of Cushing's disease during pregnancy, bilateral adrenalectomy, and, finally, the long-term psychological manifestations of hypercortisolemia. Comprehensive and an invaluable addition the literature, Cushing’s Disease is an essential reference for enhancing diagnosis and treatment of this debilitating disorder.

Book explains adrenal dysfunction

Tue, 15 Mar 2011 18:09:46 -0400

"The adrenal glands are responsible for providing the fight-or-flight hormones in response to stress. If they’re under-producing, that’s Addison’s disease, and if they’re overproducing, that’s Cushing’s syndrome.

Cushing's Syndrome due to a Pancreatic Neuroendocrine Tumor Metastatic to the Ovaries: a Clinicopathological Description of a Case.

Mon, 14 Mar 2011 13:23:40 -0400

We report the case of a 36-year-old woman with Cushing's syndrome caused by a malignant unresectable neuroendocrine carcinoma of the pancreas that developed bilateral ovarian metastases 7 years after diagnosis.

High prevalence of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas: a challenge to management

Mon, 14 Mar 2011 11:17:39 -0400

The prevalence of subclinical hypercortisolism (SH) in unilateral incidentalomas (UI) has been extensively studied; however, patients with bilateral incidentalomas (BI) have not been thoroughly investigated. We therefore aimed to describe the characteristics of patients with BI compared to their unilateral counterparts. The surgical outcome in a small number of patients is reported.

Did King Henry the VIII Have Cushing's? (Updated 3/12/11)

Sat, 12 Mar 2011 13:03:02 -0500

Henry VIII may have had two rare medical conditions (Cushing's) that could explain both his health issues later in life and the miscarriages of two of his wives.

Pituitary Tumor Video

Fri, 11 Mar 2011 18:32:47 -0500

John Atkinson, M.D., a Mayo Clinic neurosurgeon, describes diagnosis and treatment options for pituitary tumors.

Addison Disease Video

Fri, 11 Mar 2011 17:53:01 -0500

Addison Disease Video

Pituitary Terminology

Fri, 11 Mar 2011 17:25:32 -0500

Cushing's Disease

Too much ACTH secretion is rare and may be from a pituitary tumor; this is called Cushing’s disease. Symptoms of too much ACTH include weight gain, a round and red face, increased acne, purple stretch marks, hair growth and muscle weakness...

Abbreviations

Wed, 09 Mar 2011 13:07:13 -0500

Abbreviations (Updated 3/9/11) . Some abbreviations used on the boards, articles and throughout the bios

Cushing's Syndrome and Disease: A Disorder That Often Goes Undiagnosed

Wed, 09 Mar 2011 10:38:24 -0500

Obesity, excess neck fat and the ability to easily bruise are just a few signs of this commonly overlooked condition. Often it is caused by a tumor in the adrenal gland, which may be cancerous. Nancy D. Perrier, M.D., F.A.C.S., chief of the Section of Surgical Endocrinology at MD Anderson Cancer Center, discusses this disorder and the difference between the syndrome and disease.

Guest(s): Nancy D. Perrier, M.D., F.A.C.S.

Multiple endocrine neoplasia type 1 and adrenal Cushing's

Thu, 24 Feb 2011 10:33:53 -0500

Multiple endocrine neoplasia type 1 (MEN1) is typically associated with adrenocorticotropic hormone (ACTH)-dependent Cushing's. However this case illustrates a rare association between MEN1 and adrenergic Cushing's.

Arizona, Tucson: Endocrine Surgery Center at the University of Arizona

Sun, 06 Feb 2011 20:01:50 -0500

Medical Centers ~ Arizona, Tucson: Endocrine Surgery Center at the University of Arizona

Fatty Liver Associated With Cushing's Syndrome

Fri, 04 Feb 2011 21:39:07 -0500

Cushing's syndrome results from prolonged elevations in glucocorticoids in the body. Glucocorticoids are steroid hormones that affect the metabolism of glucose. A person with Cushing's syndrome has a chronic elevation of glucose in the blood that increases the risk for insulin resistance and diabetes. Fatty liver, or steatosis, is a common indicator for insulin resistance.

The UCLA Pituitary iCase of the Month

Fri, 04 Feb 2011 04:08:57 -0500

The UCLA Pituitary iCase of the Month is a recorded case presentation of a patient treated at the Ronald Reagan UCLA Medical Center. The case was presented and discussed at our monthly UCLA Pituitary Tumor Board.

The case presentation is divided into sections: Clinical History, Neuro-Imaging Findings, Operative Findings, Surgical Pathology, Outcome, and Discussion. It is a multidisciplinary conference, with each section discussed by specialists in the UCLA Pituitary Tumor Program.

Free Book: Diagnosis and Management of Pituitary Disorders (Contemporary Endocrinology)

Fri, 04 Feb 2011 03:11:12 -0500

This text provides a detailed update on current diagnostic and therapeutic techniques useful in the management of a broad spectrum of pituitary disorders. The contents reflect the multidisciplinary approach needed for patients with disorders of the pituitary gland, with contributions from both endocrinologists and neurosurgeons, as well as specialty contributions from radiologists, ophthalmologists, pathologists, radiation oncologists, and neurologists. The book focuses on each pituitary tumor subtype, and contains additional chapters related to other lesions of the sella, including tumor management during pregnancy and in the pediatric age group.

Cushie 12-Step Program

Thu, 03 Feb 2011 13:02:17 -0500

I “acquired” this from another site and changed the names to protect the innocent…

As you know many of us Cushies have had or have an addiction to Googling.

I suggest anyone who feels compelled to google symptoms go to the message boards to ask for support instead of typing these or any words such as “buffalo hump” in the google search engine. When this is done all roads lead to one thing…… You Eat Too Much!; You’re Depressed!

Recurrent Cushing’s Syndrome Due to Recurrent Adrenocortical Tumor—Fragmentation or Tumor in Ectopic Adrenal Tissue?

Wed, 02 Feb 2011 20:20:37 -0500

A 33-yr-old woman was found to have Cushing’s syndrome due to a left adrenal cortical tumor. The tumor and the surrounding adrenal gland were removed intact and in toto. Four years later, she noticed recurrent symptoms of Cushing’s syndrome, and 6 yr postoperatively, an adrenal tumor was demonstrable on computed tomography. Fourteen years after the initial procedure, a left adrenal tumor, presumably arising in ectopic adrenal tissue, was removed with relief of her symptoms of Cushing’s syndrome. The site and functional capacity of ectopic adrenal tissues are reviewed.

Corticosteroid Binding Globulin: A New Target for Cortisol-Driven Obesity

Wed, 02 Feb 2011 20:08:06 -0500

We present data suggesting that corticosteroid-binding globulin (CBG) may be the causal gene of a previously identified quantitative trait locus (QTL) associated with cortisol levels, fat, and muscle content in a pig intercross...

Diagnosed for obesity surgery in the US, 35 year Old American Lady weighing 136 kg was correctly detected of brain tumor at Fortis Hospitals Mulund

Wed, 26 Jan 2011 09:58:40 -0500

“Ms Hardin visited us with the known fact that she had to undergo Bariatric surgery through Gastric Bypass method. Detailed investigations at the hospital however revealed that she actually had a Pituitary Tumor on the right side of the pituitary gland of about 1cm in diameter. The weight gained was actually because of this pituitary tumour and not because of any case of obesity...

Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene

Wed, 26 Jan 2011 09:59:15 -0500

We report a 31 years-old female MEN1-patient, in whom hyperplasia of the parathyroid glands, prolactinoma, non functioning pancreatic endocrine carcinoma and functioning bilateral adrenal carcinomas were diagnosed. Interestingly, a not previously described in the literature data, novel germline mutation (p.E45V) in exon 2 of MEN1 gene, was detected.

Efficacy of Cabergoline in Uncured Cushing Disease After Pituitary Surgical Treatment with or without Radiotherapy.

Sun, 23 Jan 2011 19:02:26 -0500

Objective: To evaluate the efficacy of cabergoline therapy in patients with Cushing disease who remained uncured (had persistent or recurrent disease) after a pituitary surgical procedure with or without radiotherapy.

Medical Apps, Part 4: RXmindme

Sun, 23 Jan 2011 02:37:45 -0500

I often forget to take my meds. And other days, I can't remember if I took them or not.

So, here's another great (FREE!) iPhone App: Rxmindme...

Robin's Adrenal Crisis Letter

Sat, 22 Jan 2011 13:36:02 -0500

Robin has shared these two documents with us to use in case of Adrenal Crisis. She suggests laminating them or putting in a plastic page protector.

Updated: Do You Have a Favorite Health/Medical App?

Fri, 21 Jan 2011 16:39:43 -0500

Discuss here!

Pennsylvania: Pituitary Tumor Treatment at Jefferson

Thu, 20 Jan 2011 11:50:15 -0500

Jefferson neurosurgeons lead a multidisciplinary team including specialists from neurological surgery, endocrinology, otolaryngology, neuro-opthalmology and radiation oncology.

Fitness fanatic balloons from size 10 to 18 in weeks after developing tumour on her pituitary gland

Wed, 19 Jan 2011 12:53:10 -0500

...She was finally diagnosed with Cushing's syndrome, a rare tumour on the pituitary gland, after five years of anguish.

The condition, which affects fewer than one in 200,000 people, causes a small tumour to develop next to the pituitary gland,affecting the hormones released into the bloodstream.

Kathryn, who works as a carer for people with disabilities, said: 'Cushing's syndrome has transformed me into a completely different person....

Pituitary: Old Dogs learn new tricks

Tue, 18 Jan 2011 12:46:20 -0500

You know that my wife Dianna has Cushing's Disease and has suffered for well over 25 years. She has had 3 brain surgeries including having Her pituitary gland removed...

Pituitary Tumor Treatment By way of Surgery

Thu, 13 Jan 2011 15:45:02 -0500

Pituitary Tumor Treatment By way of Surgery

Addison's Disease/Adrenal Insufficiency

Thu, 27 Jan 2011 11:34:57 -0500

New! A site for people with Addison's Disease/Adrenal Insufficiency.

This is based on the fact that many pituitary patients have lost adrenal function as a result of pituitary surgery.

This site will be updated regularly.

Upcoming Cushing's Book updates

Thu, 27 Jan 2011 11:36:22 -0500

This project was started in June 2008 and put on hold due to several "life issues", one of them being the enormous amount of time it takes to apply for non-profit status. Here are some of the thoughts and ideas that will be in the book when finished, hopefully by December 2011. MaryO: some people have articles on the website like http://www.cushings-help.com/helpful_hints.htm and these: * Kate's Family Letter * Kate's Packing Suggestions For Surgery * Kate's Pituitary Surgery Observations * LindaP's Cushing's Tips

Camp Cushie Tip List (Seattle, Washington)

Sat, 12 Nov 2011 07:20:48 -0500

Camp Cushie Tip List (Seattle, Washington)

On becoming an aware patient

Sat, 24 Jul 2010 20:06:48 -0400

For all of my early life, I was the good, compliant, patient. I took whatever pills the doctor prescribed, did whatever tests h/she (most always a he) wrote for. Believed that whatever he said was the absolute truth. He had been to med school. He knew what was wrong with me even though he didn't live in my body 24/7 and experience what I did...

Cushing's Awareness Day on Jimmy Buffett's Margaritaville

Fri, 08 Apr 2011 17:22:19 -0400

Cushing's Awareness Day at Jimmy Buffett's Margaritaville The picture in this photo is of Donna Sellers, her son, John, and Sonny Perdue, Governor of the State of Georgia. Donna is the president of John's Foundation for Cushing's Awareness and mother of a Cushing's patient. The foundation can be found at http://www.jfcainc.com/

The first Audio Cushing's announcement: upcoming interview with Dr Ted Friedman

Sat, 17 Jan 2009 23:47:17 -0500

This first "test" announcement is about the upcoming interview with Dr Ted Friedman.

Note that the date of this interview has changed to January 29, 2009 at 8:30PM eastern.

Future audio announcements will include other news items and happenings in the Cushing's Community.

Testimonials

Mon, 17 May 2010 15:28:10 -0400

They're Saying Such Nice Things...

Newest comments: "I'm so grateful to God for leading me to this site. For weeks I would cry and drive an hour and a half to work praying. Pleading with God, telling him I need help, that I can't live like this. One small conversation with Grandmother, the name of a disease called Cushing's, and my computer and I found the most wonderful group of people in the world! This is the beginning of my journey to prove to the world I'm not crazy, I'm not lazy, I'm not a bad woman, daughter, mother. The time that everyone here takes to post, respond, and communicte with each other gives me hope. I sit here and read and cry almost every day. I cry for the pain and depression I see others going through because I can relate. I cry for the people who are making break throughs. I cry for the people overwhelmed with excitement and joy for a diagnosis, and I cry for all of you who give your time and experience to encourage and lead beginners such as myself. I'm so scared of the future, but at the same time, I'm so hopeful too.

So here's my Thank You! Thank You! Thank You! I'm blessed to have found you all.. "

"MaryO - thanks so much for having this board. When I was first diagnosed, there was practically nothing on the internet as far as support. I wasn't able to find much research about my health issues. I had to do most of the research by hand at the library and by reading medical textbooks and journals. I appreciate you having this here for everyone to share their experiences and to support each other, to be able to share information when we find it, and to vent when we need to."

"My key was the very best minimally invasive surgeon I could find on the planet. I found him, with much help from selfless and thorough Cushing's advice source MaryO'Connor's Cushings-help.com. Mary is my true hero in the lifelong Cushing's story of my time. Without her dedication to Cushing's and helping other people find help, I would be somewhere today lost & still fluttering in the wind, undiagnosed or probably dead.

Mary runs her site out of pocket, so please stop over and donate to her cause, I use Paypal. :) She is truly and directly saving lives with her work, and at the very least should not have to be worried about money to keep the place going. She also has health issues of her own that I would prefer to see magically disappear and fix, for Mary deserves a long healthy happy life with Tom. :)"

You are sensational in your commitment and perseverance for our cause. I admire and thank you."

"I'm on my way to Houston tomorrow for a date with a surgeon. Wanted to thank you again before I go. I know you are far too modest to believe me, but without your help. I would never have been diagnosed and ever have had a shot at getting better. Definately wouldn't have had any hope!

You are doing a great thing and I credit you more than the doctors for saving my life. The doctors are doing their jobs and thank goodness for that but without you, I would never have learned to trust my instincts and to fight for myself let alone find the doctors that could help rather than make things worse!

So I will be off in Houston for my big adventure and coming back on my birthday. Flying back first class, first time ever but I will be too drugged to appreciate it! :-) Just wanted you to know that while I will be away for 10 days, I will still be stalking you in my heart!

Thank you & Love you!!!"

What a blessing you are to so many people. Did you start up this website yourself??? If you did - wow..that was a lot of work. It is an incredible resource and help to hundreds and thousands...you have helped so many people you’ll never know how many people’s lives this website has helped – that is a staggering thought!!!! I hope you get the credit you deserve. I bet it is humbling sometimes to think about I am sure. I thank you for you gift to me and I am just a newbie!!!"

"I so enjoyed the interview with Cushing's Help Founder, Mary O'Connor. Jayne, you did a great job! I've had the pleasure of knowing Mary since before Cushings-Help.com became a reality. Mary puts an unusual amount of time and effort into her incredibly informative and invaluable Web site. Mary IS Cushing's Help. If there's any new technology where Mary can spread the word about Cushing's, she'll find it. This new blogtalkradio is another excellent venue where Mary can continue her endless help for those suffering from Cushing's and related disorders. I'm personally so proud of all that she's accomplished, especially when through it all, she's still dealing with her own health issues, but that doesn't stop her! I'm proud to call her my "friend." Keep up the good work, MaryO! Alice Stamm (aka Dearest)"

In Memory of Natalie Fay

Mon, 26 Apr 2010 12:44:05 -0400

Natalie Fay (Natalie65), died April 21, 2008.

She was only 42 and had recently had a bilateral adrenalectomy (BLA).

Robin's "Flake"

Sat, 20 Nov 2010 10:33:49 -0500

Robin's "Flake" includes Cushing's Research, Travel Info for Dr. Friedman and Dr. Ludlam; Bookmarks and General Cushing's/Health Info to share.

Helpful Hints updated

Fri, 08 Oct 2010 10:59:06 -0400

A new hint for Adrenal Crisis was added

Interactive!

Thu, 12 Aug 2010 10:30:22 -0400

This Interactive page includes things YOU can do to help yourself and other Cushies.

Cushing's Awareness Silicone Wristbands are back!

5 minutes of caring, daily suggestions full of practical tips and helpful hints designed to motivate.